Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.59 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.51 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.51 |
| ▸ | FAAH | O00519 | 8/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20504730 | 0.92 | PTPN1 (0.54) | PTPN1LTB4RLTB4R2PPARAKDM4E | |
| SCHEMBL28423316 | 0.89 | CA12 (0.55) | PTPN1PPARATP53TSHR | |
| SCHEMBL5007630 | 0.85 | L3MBTL1 (0.50) | PTPN1L3MBTL1 | |
| SCHEMBL4992797 | 0.84 | PTPN1 (0.50) | PTPN1LTB4RLTB4R2KDM4EL3MBTL1 | |
| SCHEMBL26724903 | 0.84 | NFKB1 (0.49) | PTPN1LTB4RLTB4R2KDM4EL3MBTL1 | |
| SCHEMBL8277236 | 0.83 | PTPN1 (0.55) | PTPN1FAAHKDM4EL3MBTL1 | |
| SCHEMBL29109655 | 0.83 | PPARA (0.58) | PTPN1PPARATP53TSHRL3MBTL1 | |
| SCHEMBL6840729 | 0.83 | KMT2A (0.51) | PTPN1PPARAKDM4ETP53TSHR | |
| SCHEMBL10339837 | 0.83 | TP53 (0.50) | PTPN1PPARATP53TSHR | |
| SCHEMBL4960097 | 0.83 | PTPN1 (0.60) | PTPN1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3928836-A1 | N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2021-12-29 | — | — | EP | disclosed |