Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.38 |
| ▸ | NQO2 | P16083 | 6/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | NQO1 | P15559 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24136191 | 0.83 | L3MBTL1 (0.34) | CYP19A1NQO2PRMT1KMT2AMC4R | |
| SCHEMBL8015186 | 0.72 | RHEB (0.47) | CYP19A1NQO2KMT2AMAPTKDM4E | |
| SCHEMBL18271426 | 0.67 | MAPT (0.44) | KMT2AMAPTRXFP1TSHRNPSR1 | |
| SCHEMBL15993878 | 0.67 | TDP1 (0.47) | CYP19A1NQO2KMT2AMAPTTSHR | |
| SCHEMBL8429646 | 0.66 | CYP2C9 (0.57) | KMT2AMAPTNQO1TSHRKDM4E | |
| SCHEMBL17013396 | 0.65 | L3MBTL1 (0.49) | KMT2AMAPTTSHRNPSR1KDM4E | |
| SCHEMBL16157998 | 0.64 | BRD9 (0.40) | CYP19A1NQO2MAPTBRD9TAAR1 | |
| SCHEMBL29764716 | 0.63 | L3MBTL1 (0.35) | CYP19A1NQO2MC4RBRD9TAAR1 | |
| SCHEMBL25469348 | 0.62 | KDM4E (0.43) | KMT2AMAPTTSHRKDM4EL3MBTL1 | |
| SCHEMBL644451 | 0.62 | KMT2A (0.55) | CYP19A1NQO2KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3928836-A1 | N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2021-12-29 | — | — | EP | disclosed |