Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 17/20 | 0.48 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.32 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24144264 | 0.92 | NR1D1 (0.52) | NR1D1NFATC1GSK3BDYRK1AAAK1 | |
| SCHEMBL24143302 | 0.83 | NR1D1 (0.48) | NR1D1NFATC1GSK3BDYRK1AAAK1 | |
| SCHEMBL24143250 | 0.83 | NR1D1 (0.49) | NR1D1AAK1 | |
| SCHEMBL24143522 | 0.82 | NR1D1 (0.72) | NR1D1 | |
| SCHEMBL24143354 | 0.82 | CDK2 (0.34) | NR1D1CDK2 | |
| SCHEMBL24143293 | 0.81 | NR1D1 (0.57) | NR1D1 | |
| SCHEMBL24144036 | 0.81 | NR1D1 (0.44) | NR1D1AAK1ROCK2CDK1PRKACA | |
| SCHEMBL24143335 | 0.79 | NR1D1 (0.38) | NR1D1GSK3BDYRK1AAAK1ROCK2 | |
| SCHEMBL24143301 | 0.79 | NR1D1 (0.46) | NR1D1GSK3BDYRK1A | |
| SCHEMBL24144895 | 0.77 | NR1D1 (0.59) | NR1D1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021263278-A1 | REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-12-30 | — | — | WO | disclosed |