Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 11/20 | 0.46 |
| ▸ | METAP2 | P50579 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24143302 | 0.84 | NR1D1 (0.48) | NR1D1METAP2GSK3BDYRK1ACHEK1 | |
| SCHEMBL24144264 | 0.82 | NR1D1 (0.52) | NR1D1METAP2GSK3BDYRK1A | |
| SCHEMBL24142952 | 0.82 | NR1D1 (0.67) | NR1D1 | |
| SCHEMBL24143250 | 0.80 | NR1D1 (0.49) | NR1D1CHEK1 | |
| SCHEMBL24143794 | 0.79 | OPRM1 (0.44) | NR1D1METAP2GSK3BDYRK1ADRD2 | |
| SCHEMBL24144342 | 0.79 | NR1D1 (0.48) | NR1D1GSK3BDYRK1A | |
| SCHEMBL24144688 | 0.79 | NR1D1 (0.46) | NR1D1DYRK1A | |
| SCHEMBL24143293 | 0.78 | NR1D1 (0.57) | NR1D1 | |
| SCHEMBL24144642 | 0.77 | NR1D1 (0.49) | NR1D1GSK3BDYRK1A | |
| SCHEMBL24143043 | 0.77 | NR1D1 (0.45) | NR1D1GSK3BDYRK1ACHEK1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021263278-A1 | REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-12-30 | — | — | WO | disclosed |