Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 13/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24144264 | 0.89 | NR1D1 (0.52) | NR1D1GSK3BDYRK1ANFATC1METAP2 | |
| SCHEMBL24143293 | 0.84 | NR1D1 (0.57) | NR1D1 | |
| SCHEMBL24143250 | 0.84 | NR1D1 (0.49) | NR1D1CHEK1AAK1 | |
| SCHEMBL24143301 | 0.84 | NR1D1 (0.46) | NR1D1GSK3BDYRK1ACHEK1METAP2 | |
| SCHEMBL24144679 | 0.84 | NR1D1 (0.49) | NR1D1GSK3B | |
| SCHEMBL24143779 | 0.83 | NR1D1 (0.50) | NR1D1NR4A2GSK3BDYRK1ANFATC1 | |
| SCHEMBL24144342 | 0.83 | NR1D1 (0.48) | NR1D1GSK3BDYRK1ANFATC1AAK1 | |
| SCHEMBL24143043 | 0.81 | NR1D1 (0.45) | NR1D1NR4A2GSK3BDYRK1ACHEK1 | |
| SCHEMBL24144870 | 0.81 | NR1D1 (0.48) | NR1D1NR4A2GSK3BDYRK1ANFATC1 | |
| SCHEMBL24143303 | 0.80 | NR1D1 (0.73) | NR1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021263278-A1 | REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-12-30 | — | — | WO | disclosed |