Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29370549 | 0.98 | MAPT (0.50) | MAPTTSHRKDM4ECA12CA1 | |
| SCHEMBL27392334 | 0.98 | MAPT (0.50) | MAPTTSHRKDM4ECA12CA1 | |
| SCHEMBL18172 | 0.98 | MAPT (0.50) | MAPTTSHRKDM4ECA12CA1 | |
| SCHEMBL517747 | 0.95 | MAPT (0.48) | MAPTTSHRKDM4ECA12CA1 | |
| Hydrochloric Acid SCHEMBL30018404 | 0.95 | MAPT (0.48) | MAPTTSHRKDM4ECA12CA1 | |
| Methane SCHEMBL11211553 | 0.95 | MAPT (0.48) | MAPTTSHRKDM4ECA12CA1 | |
| Cyclopropane SCHEMBL29291393 | 0.95 | MAPT (0.48) | MAPTTSHRKDM4ECA12CA1 | |
| SCHEMBL7259924 | 0.95 | MAPT (0.48) | MAPTTSHRKDM4ECA12CA1 | |
| SCHEMBL8215775 | 0.95 | MAPT (0.48) | MAPTTSHRKDM4ECA12CA1 | |
| Hydrochloric Acid SCHEMBL5370795 | 0.95 | MAPT (0.48) | MAPTTSHRKDM4ECA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385271-A1 | Tetrahydroquinolines and method of preparation | EASTMAN KODAK COMPANY (US) | 1990-09-05 | — | — | EP | claimed |
| EP-2076524-B1 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PLC (GB) | 2016-04-20 | — | — | EP | disclosed |
| US-8735583-B2 | Chiral phosphorus compound | JOHNSON MATTHEY PUBLIC LIMITED CO. (GB) | 2014-05-27 | — | — | US | disclosed |
| US-20130150583-A1 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2013-06-13 | — | — | US | disclosed |
| US-8404843-B2 | Chiral phosphorus compound | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2013-03-26 | — | — | US | disclosed |
| US-20120264940-A1 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2012-10-18 | — | — | US | disclosed |
| US-8222415-B2 | Chiral phosphorus compound | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2012-07-17 | — | — | US | disclosed |
| US-20120004411-A9 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PLC (GB) | 2012-01-05 | — | — | US | disclosed |
| US-20100240898-A1 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PLC (GB) | 2010-09-23 | — | — | US | disclosed |
| EP-2076524-A1 | CHIRAL PHOSPHORUS COMPOUND | Johnson Matthey Public Limited Company (GB) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008041029-A1 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PLC (GB) | 2008-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264940-A1 | CHIRAL PHOSPHORUS COMPOUND | PIK3CA, RECQL, P2RY1 | MAPT 4310/4885TSHR 1983/4885KDM4E 3774/4885 |
| US-20120004411-A9 | CHIRAL PHOSPHORUS COMPOUND | PIK3CA, RECQL, P2RY1 | MAPT 4310/4885TSHR 1983/4885KDM4E 3774/4885 |
| US-20100240898-A1 | CHIRAL PHOSPHORUS COMPOUND | PIK3CA, RECQL, P2RY1 | MAPT 4310/4885TSHR 1983/4885KDM4E 3774/4885 |
| US-20130150583-A1 | CHIRAL PHOSPHORUS COMPOUND | ALPP, PTH1R, CALCR | MAPT 4361/4885TSHR 818/4885KDM4E 4167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.