Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9257901 | 0.91 | PTGS2 (0.46) | ALOX5LMNAPTGS2FAAHALB | |
| SCHEMBL5444246 | 0.82 | ESR1 (0.52) | ALOX5LMNAPTGS2SMN1; SMN2FAAH | |
| SCHEMBL621292 | 0.82 | BRD4 (0.50) | ALDH1A1CES2CES1PTGS2SMN1; SMN2 | |
| SCHEMBL8956391 | 0.82 | PTGS2 (0.61) | ALOX5LMNAALDH1A1PTGS2ALB | |
| SCHEMBL27774472 | 0.81 | ALOX5 (0.48) | ALOX5ACHESTAT3LMNAALDH1A1 | |
| SCHEMBL11721635 | 0.81 | CYP1A2 (0.46) | LMNAPTGS2CYP2C9PTGS1AKR1C3 | |
| SCHEMBL8427951 | 0.80 | GRM7 (0.45) | LMNAALDH1A1CES2CES1PTGS2 | |
| SCHEMBL8427952 | 0.80 | GRM7 (0.45) | LMNAALDH1A1CES2CES1PTGS2 | |
| SCHEMBL28776369 | 0.80 | PTGS2 (0.39) | ALOX5LMNAPTGS2FAAHALB | |
| SCHEMBL2291864 | 0.80 | CYP1A2 (0.48) | ALOX5LMNAALDH1A1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112294816-B | Application of ethyl benzamide compound in preparation of local anesthetic | 四川大学华西医院 | 2021-07-30 | — | — | CN | disclosed |
| CN-112294816-A | Application of ethyl benzamide compound in preparation of local anesthetic | 四川大学华西医院 | 2021-02-02 | — | — | CN | disclosed |
| CN-102803269-B | Thieno [2,3-B ] pyrimidinedione activators of AMPK and therapeutic uses thereof | POXEL (FR) | 2016-01-13 | — | — | CN | disclosed |
| CN-102803269-A | Thieno [2,3-B ] pyrimidinedione activators of AMPK and therapeutic uses thereof | POXEL | 2012-11-28 | — | — | CN | disclosed |
| EP-1559716-B1 | PYRAZOLONAPHTHYRIDINE DERIVATIVE | ASKA PHARM CO LTD (JP) | 2011-09-14 | — | — | EP | disclosed |
| US-20100093782-A1 | Pyrazolonaphthyridine derivatives | KANAZAWA HASHIME | 2010-04-15 | — | — | US | disclosed |
| US-7608716-B2 | Pyrazolonaphthyridine derivative | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2009-10-27 | — | — | US | disclosed |
| US-7012138-B1 | Chiral polysaccharide esters, one of the methods for preparing them and their uses for obtaining optically enriched acids or for chiral chromatography | UNIVERSITE DE DROIT D'ECONOMIE ET DES SCIENCES D'AIZ-MARSEILLE (FR) | 2006-03-14 | — | — | US | disclosed |
| US-20060040972-A1 | Pyrazolonaphthyridine derivative | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2006-02-23 | — | — | US | disclosed |
| EP-1559716-A1 | PYRAZOLONAPHTHYRIDINE DERIVATIVE | Grelan Pharmaceutical Co., Ltd. (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-5703074-A | OSTEOPOROSIS | ADIR ET COMPAGNIE (FR) | 1997-12-30 | — | — | US | disclosed |
| CN-1107838-A | Tricyclic indole-2-carboxylic acid derivatives | SUMITOMO PHARMA (JP) | 1995-09-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040972-A1 | Pyrazolonaphthyridine derivative | PDE3B, PDE3A, PDE4A | ALOX5 2455/4885ACHE 862/4885STAT3 2769/4885 |
| US-20100093782-A1 | Pyrazolonaphthyridine derivatives | PDE3B, PDE3A, PDE4A | ALOX5 2380/4885ACHE 877/4885STAT3 2728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.