Sugi Predict

Sugi Predict / Compounds / SCHEMBL621292

SCHEMBL621292

SCHEMBL621292

CC(C(=O)Cl)c1ccc(Cl)cc1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ BRD4 O60885 1/20 0.50
▸ FFAR2 O15552 4/20 0.48
▸ ADRB2 P07550 1/20 0.48
▸ HDAC4 P56524 1/20 0.45
▸ HDAC7 Q8WUI4 1/20 0.45
▸ HDAC5 Q9UQL6 1/20 0.45
▸ SMN1; SMN2 Q16637 2/20 0.42
▸ POLB P06746 1/20 0.42
▸ GAA P10253 1/20 0.42
▸ HPGD P15428 1/20 0.42
▸ MEN1 O00255 1/20 0.42
▸ RAB9A P51151 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ CES2 O00748 1/20 0.41
▸ CES1 P23141 1/20 0.41
▸ PTGS2 P35354 1/20 0.41
▸ SLC6A4 P31645 1/20 0.41
▸ SLC6A3 Q01959 1/20 0.41
▸ ALDH1A1 P00352 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9257901 0.91 PTGS2 (0.46) BRD4PTGS2
SCHEMBL27536656 0.84 BRD4 (0.52) BRD4FFAR2ADRB2HDAC4HDAC7
SCHEMBL2415101 0.82 ALOX5 (0.46) SMN1; SMN2MEN1KMT2ACES2CES1
SCHEMBL5444246 0.82 ESR1 (0.52) SMN1; SMN2GAAMEN1KMT2APTGS2
SCHEMBL8956391 0.82 PTGS2 (0.61) HPGDPTGS2ALDH1A1
SCHEMBL1590331 0.82 PTGS2 (0.61) BRD4FFAR2ADRB2POLBMEN1
SCHEMBL598280 0.82 PTGS2 (0.61) BRD4FFAR2ADRB2POLBMEN1
SCHEMBL15695554 0.82 BRD4 (0.61) BRD4FFAR2ADRB2HDAC4HDAC7
SCHEMBL121108 0.82 PTGS2 (0.61) BRD4FFAR2ADRB2POLBMEN1
SCHEMBL12225982 0.82 BRD4 (0.61) BRD4FFAR2ADRB2HDAC4HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3704117-B1 AZABICYCLO DERIVATIVES FOR TREATING OCULAR DISORDERS ALCON INC (CH) 2026-01-28 — — EP disclosed
US-12247028-B2 Azabicyclo and diazepine derivatives ALCON INC. (CH) 2025-03-11 — — US disclosed
US-20240132497-A1 AZABICYCLO AND DIAZEPINE DERIVATIVES ALCON INC. (CH) 2024-04-25 — — US disclosed
US-11884666-B2 Azabicyclo and diazepine derivatives ALCON INC. (CH) 2024-01-30 — — US disclosed
US-20220267328-A1 AZABICYCLO AND DIAZEPINE DERIVATIVES ALCON INC. (CH) 2022-08-25 — — US disclosed
US-11306090-B2 Azabicyclo and diazepine derivatives ALCON INC. (CH) 2022-04-19 — — US disclosed
US-20210179616-A1 AZABICYCLO AND DIAZEPINE DERIVATIVES ALCON INC. (CH) 2021-06-17 — — US disclosed
US-20210179616-A1 AZABICYCLO AND DIAZEPINE DERIVATIVES ALCON INC. (CH) 2021-06-17 — — US disclosed
EP-3704117-A1 AZABICYCLO AND DIAZEPINE DERIVATIVES FOR TREATING OCULAR DISORDERS ALCON INC. (CH) 2020-09-09 — — EP disclosed
CN-111247147-A Azabicyclo and diazepatriene derivatives useful for treating ocular disorders 爱尔康公司 2020-06-05 — — CN disclosed
CN-1078586-C Phenylalkanamide derivatives and agrohor-ticultural bactericides KUMIAI CHEMICAL INDUSTRY CO (JP) 2002-01-30 — — CN disclosed
US-6075055-A EXCELLENT FUNGICIDAL ACTIVITIES WITH REGARD TO RICE BLAST AND THE LIKE, WHILE AT THE SAME TIME DO NOT HINDER DESIRABLE PLANT GROWTH KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2000-06-13 — — US disclosed
EP-0854134-B1 PHENYLALKANAMIDE DERIVATIVES AND AGROHORTICULTURAL BACTERICIDES KUMAII CHEMICAL INDUSTRY CO LT (JP) 2000-04-26 — — EP disclosed
US-5847211-A Substituted 1H-3-Aryl-pyrrolidine-2,4-dione derivatives BAYER AKTIENGESELLSCHAFT (DE) 1998-12-08 — — US disclosed
CN-1192728-A Phenylalkanamide derivatives and agricultural or horticultural fungicides KUMIAI CHEMICAL INDUSTRY CO (JP) 1998-09-09 — — CN disclosed
EP-0854134-A1 PHENYLALKANAMIDE DERIVATIVES AND AGROHORTICULTURAL BACTERICIDES KumaiI Chemical Industry Co., Ltd. (JP) 1998-07-22 — — EP disclosed
US-5622917-A PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-04-22 — — US disclosed
US-4073936-A Hypolipidemic allene carboxylic esters SANDOZ, INC. (US) 1978-02-14 — — US disclosed
US-4011339-A ANTIINFLAMMATORY AGENTS SANDOZ, INC. (US) 1977-03-08 — — US disclosed
US-3981888-A Process for preparing (1-oxo-2-phenyl, halophenyl or thienyl-2-methyl-6,7-dichloro-5-indanyloxy)acetic acid MERCK & CO., INC. (US) 1976-09-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11884666-B2 Azabicyclo and diazepine derivatives CHRM3, CHRM5, CHRNA5 BRD4 189/4885FFAR2 421/4885ADRB2 26/4885
US-20240132497-A1 AZABICYCLO AND DIAZEPINE DERIVATIVES CHRM3, CHRM5, CHRNA5 BRD4 189/4885FFAR2 421/4885ADRB2 26/4885
US-20210179616-A1 AZABICYCLO AND DIAZEPINE DERIVATIVES CHRM3, CHRM5, CHRNA5 BRD4 189/4885FFAR2 421/4885ADRB2 26/4885
US-20220267328-A1 AZABICYCLO AND DIAZEPINE DERIVATIVES CHRM3, CHRM5, CHRNA5 BRD4 189/4885FFAR2 421/4885ADRB2 26/4885
US-12247028-B2 Azabicyclo and diazepine derivatives CHRM3, CHRM5, CHRNA5 BRD4 189/4885FFAR2 421/4885ADRB2 26/4885
US-11306090-B2 Azabicyclo and diazepine derivatives CHRM3, CHRM5, CHRNA5 BRD4 189/4885FFAR2 421/4885ADRB2 26/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.