Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.49 |
| ▸ | HPGDS | O60760 | 2/20 | 0.49 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.49 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.49 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.49 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1246894 | 0.85 | PARP10 (0.59) | KMT2ANPC1GAARAB9ASMN1; SMN2 | |
| SCHEMBL28106095 | 0.83 | PARP10 (0.66) | KMT2ANPC1GAARAB9ASMN1; SMN2 | |
| SCHEMBL24124449 | 0.83 | PARP10 (0.66) | KMT2ASMN1; SMN2PARP10MKNK1MKNK2 | |
| SCHEMBL24124450 | 0.83 | PARP10 (0.66) | KMT2ASMN1; SMN2PARP10MKNK1MKNK2 | |
| SCHEMBL24124455 | 0.80 | PARP10 (0.79) | KMT2ASMN1; SMN2PARP10CHEK2PARP15 | |
| SCHEMBL22724717 | 0.80 | PARP10 (0.79) | KMT2ASMN1; SMN2PARP10CHEK2PARP15 | |
| SCHEMBL24155677 | 0.79 | MEN1 (0.70) | KMT2ANPC1GAARAB9ASMN1; SMN2 | |
| Diphenylether SCHEMBL3939335 | 0.78 | PARP10 (0.96) | KMT2ASMN1; SMN2PARP10PARP15ALDH1A1 | |
| SCHEMBL30576778 | 0.76 | PARP10 (0.58) | KMT2APARP10PARP15ALDH1A1PARP14 | |
| Terephthalamide SCHEMBL4205368 | 0.76 | PARP10 (1.00) | KMT2ASMN1; SMN2PARP10PARP15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210403456-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF EPILEPSY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2021-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210403456-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF EPILEPSY | SLC6A11, SCN1A, SCN1B | KMT2A 279/4885NPC1 1298/4885GAA 3101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.