Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 6/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14841950 | 0.83 | ALDH1A1 (0.39) | KCNQ2HDAC6HDAC3HDAC1HDAC7 | |
| SCHEMBL28095748 | 0.81 | SPR (0.38) | KCNQ2HDAC6HDAC3HDAC1HDAC7 | |
| SCHEMBL9124207 | 0.79 | NOTUM (0.50) | KCNQ2HDAC6HDAC3HDAC1HDAC7 | |
| SCHEMBL28095772 | 0.78 | KCNQ2 (0.38) | KCNQ2HDAC6HDAC3HDAC1HDAC7 | |
| SCHEMBL22135240 | 0.77 | NAMPT (0.48) | CSNK1ENAMPTPOLBMEN1GAA | |
| SCHEMBL15998893 | 0.75 | BLM (0.47) | KCNQ2HDAC6HDAC3HDAC1HDAC7 | |
| SCHEMBL9121077 | 0.75 | GRM5 (0.51) | HDAC6AVPR2AVPR1AALDH1A1POLB | |
| SCHEMBL14248999 | 0.75 | RIPK1 (0.48) | KCNQ2HDAC6HDAC3HDAC1HDAC7 | |
| SCHEMBL4404356 | 0.71 | SPR (0.39) | KCNQ2HDAC6HDAC3HDAC1HDAC7 | |
| SCHEMBL31555255 | 0.70 | AVPR1A (0.35) | KCNQ2SPRPARP1AVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3793565-B1 | MCL-1 INHIBITORS | GILEAD SCIENCES INC (US) | 2022-01-05 | — | — | EP | disclosed |