Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | RECQL | P46063 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24169983 | 0.82 | NOTUM (0.43) | NOTUMALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL16479227 | 0.81 | ALDH1A1 (0.49) | NOTUMALDH1A1CHRM2CHRM4CHRM1 | |
| SCHEMBL17320372 | 0.80 | GRM5 (0.45) | — | |
| SCHEMBL4572836 | 0.80 | NOTUM (0.47) | NOTUMALDH1A1CHRM2CHRM4CHRM1 | |
| SCHEMBL21208732 | 0.78 | NOTUM (0.46) | NOTUMALDH1A1CHRM2CHRM4CHRM1 | |
| SCHEMBL24169797 | 0.78 | ALDH1A1 (0.70) | ALDH1A1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL3437431 | 0.77 | NOTUM (0.51) | NOTUMALDH1A1CHRM2CHRM4CHRM1 | |
| SCHEMBL25818505 | 0.77 | ALDH1A1 (0.65) | NOTUMALDH1A1CHRM2CHRM4CHRM1 | |
| SCHEMBL13961196 | 0.76 | NOTUM (0.50) | NOTUMALDH1A1CHRM2CHRM4CHRM1 | |
| SCHEMBL14149496 | 0.75 | KDM4E (0.46) | NOTUMALDH1A1CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3405454-B1 | INDOLINE DERIVATIVES, COMPOSITIONS COMPRISING THEM AND USES THEREOF | YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD (IL) | 2021-12-29 | — | — | EP | disclosed |