Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.71 |
| ▸ | TAS1R3 | Q7RTX0 | 8/20 | 0.58 |
| ▸ | TAS1R1 | Q7RTX1 | 8/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28858120 | 0.89 | HTT (0.74) | HTTTAS1R3TAS1R1HDAC3HDAC1 | |
| SCHEMBL31069924 | 0.83 | CA2 (0.67) | HTTTAS1R3TAS1R1HDAC3HDAC1 | |
| SCHEMBL13375870 | 0.83 | TAS1R3 (0.65) | HTTTAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL24193420 | 0.81 | TAS1R3 (0.58) | HTTTAS1R3TAS1R1ALDH1A1L3MBTL1 | |
| SCHEMBL22747924 | 0.81 | PRSS1 (0.59) | TAS1R3TAS1R1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL21078080 | 0.79 | TAS1R3 (0.58) | HTTTAS1R3TAS1R1ALDH1A1GAA | |
| SCHEMBL9128648 | 0.79 | ALDH1A1 (0.71) | HTTTAS1R3TAS1R1HDAC3HDAC1 | |
| SCHEMBL30868632 | 0.78 | TAS1R3 (0.77) | HTTTAS1R3TAS1R1ALDH1A1LMNA | |
| SCHEMBL310748 | 0.78 | TAS1R3 (0.52) | HTTTAS1R3TAS1R1HDAC3HDAC1 | |
| SCHEMBL165896 | 0.77 | PRSS1 (0.61) | TAS1R3TAS1R1ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858879-B2 | PARG inhibitors and method of use thereof | CITY OF HOPE (US) | 2024-01-02 | — | — | US | disclosed |
| US-20220002231-A1 | PARG INHIBITORS AND METHOD OF USE THEREOF | CITY OF HOPE | 2022-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220002231-A1 | PARG INHIBITORS AND METHOD OF USE THEREOF | PARG, PARP12, PARP15 | HTT 2495/4885TAS1R3 4009/4885TAS1R1 4156/4885 |
| US-11858879-B2 | PARG inhibitors and method of use thereof | PARG, PARP12, PARP15 | HTT 2495/4885TAS1R3 4009/4885TAS1R1 4156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.