Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12180488 | 0.82 | LMNA (0.57) | LMNATDP1PTGDR2L3MBTL1HTT | |
| SCHEMBL1370542 | 0.77 | LMNA (0.38) | LMNATDP1PTGDR2L3MBTL1ABL1 | |
| SCHEMBL14978748 | 0.77 | PSEN1 (0.41) | LMNATDP1PTGDR2ABL1PSEN1 | |
| SCHEMBL1755240 | 0.77 | FLT1 (0.43) | LMNATDP1PTGDR2ALDH1A1MAPT | |
| SCHEMBL21331687 | 0.76 | ALDH1A1 (0.42) | LMNATDP1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL28037659 | 0.75 | ALDH1A1 (0.38) | LMNATDP1HTTALDH1A1MAPT | |
| SCHEMBL28037211 | 0.74 | ALDH1A1 (0.41) | LMNATDP1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL28037182 | 0.74 | ALDH1A1 (0.41) | LMNATDP1ALDH1A1MAPTSMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL28038067 | 0.74 | ALDH1A1 (0.41) | LMNATDP1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL14120260 | 0.74 | LMNA (0.43) | LMNATDP1PTGDR2L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858879-B2 | PARG inhibitors and method of use thereof | CITY OF HOPE (US) | 2024-01-02 | — | — | US | disclosed |
| US-20220002231-A1 | PARG INHIBITORS AND METHOD OF USE THEREOF | CITY OF HOPE | 2022-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220002231-A1 | PARG INHIBITORS AND METHOD OF USE THEREOF | PARG, PARP12, PARP15 | LMNA 864/4885TDP1 284/4885PTGDR2 3245/4885 |
| US-11858879-B2 | PARG inhibitors and method of use thereof | PARG, PARP12, PARP15 | LMNA 864/4885TDP1 284/4885PTGDR2 3245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.