Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.41 |
| ▸ | BRD1 | O95696 | 1/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9963190 | 0.84 | KMT2A (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12180488 | 0.82 | LMNA (0.57) | LMNATDP1PTGDR2 | |
| SCHEMBL4126980 | 0.79 | POLB (0.48) | BRD1BRPF1PTGS2LMNATDP1 | |
| SCHEMBL15794097 | 0.79 | IDO1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL16022234 | 0.79 | PSEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20149227 | 0.79 | CA1 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3757908 | 0.78 | PTGS2 (0.54) | BRD1BRPF1PTGS2ALDH3A1 | |
| SCHEMBL24176361 | 0.77 | LMNA (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1370542 | 0.77 | LMNA (0.38) | LMNATDP1PTGDR2CA12CA1 | |
| SCHEMBL1755240 | 0.77 | FLT1 (0.43) | PTGS2LMNATDP1PTGS1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150259352-A1 | Chemical Compounds | PFIZER LTD (GB) | 2015-09-17 | — | — | US | disclosed |
| US-20150105396-A1 | Chemical Compounds | PFIZER LTD (GB) | 2015-04-16 | — | — | US | disclosed |
| US-8952008-B2 | Chemical compounds | PFIZER LIMITED (GB) | 2015-02-10 | — | — | US | disclosed |
| US-20140309226-A1 | PIPERIDINYL-SUBSTITUTED CYCLIC UREAS AS GPR119 MODULATORS | ARRAY BIOPHARMA, INC. | 2014-10-16 | — | — | US | disclosed |
| US-20140256756-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA, INC. | 2014-09-11 | — | — | US | disclosed |
| US-20140171435-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2014-06-19 | — | — | US | disclosed |
| WO-2014091368-A1 | IMIDAZOPYRIDAZINE DERIVATIVES AS GABAA RECEPTOR MODULATORS | PFIZER LIMITED (GB) | 2014-06-19 | — | — | WO | disclosed |
| WO-2013074641-A1 | PIPERIDINYL- SUBSTITUTED CYCLIC UREAS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2013-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256756-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | GPR119, GPR139, GLP1R | PSEN1 1352/4885PSEN2 642/4885APH1B 1096/4885 |
| US-20140309226-A1 | PIPERIDINYL-SUBSTITUTED CYCLIC UREAS AS GPR119 MODULATORS | GPR119, UTS2R, GPR139 | PSEN1 2448/4885PSEN2 1277/4885APH1B 3366/4885 |
| US-20150259352-A1 | Chemical Compounds | GABRA5, GABRA4, GABRA3 | PSEN1 3341/4885PSEN2 3926/4885APH1B 4222/4885 |
| US-20150105396-A1 | Chemical Compounds | GABRA5, GABRA4, GABRA3 | PSEN1 3341/4885PSEN2 3926/4885APH1B 4222/4885 |
| US-20140171435-A1 | Chemical Compounds | GABRA5, GABRA4, GABRA3 | PSEN1 3341/4885PSEN2 3926/4885APH1B 4222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.