Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 3/20 | 0.56 |
| ▸ | ACE | P12821 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | CPA1 | P15085 | 2/20 | 0.50 |
| ▸ | CPA2 | P48052 | 2/20 | 0.50 |
| ▸ | CPA4 | Q9UI42 | 2/20 | 0.50 |
| ▸ | CMA1 | P23946 | 1/20 | 0.50 |
| ▸ | CTRC | Q99895 | 1/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.49 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | CPB1 | P15086 | 1/20 | 0.49 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24178168 | 0.94 | CTSB (0.58) | CTSBCPA1CPA2CPA4CMA1 | |
| SCHEMBL24178174 | 0.94 | CTSB (0.58) | CTSBCPA1CPA2CPA4CMA1 | |
| SCHEMBL13706577 | 0.92 | CTSB (0.61) | CTSBCPA1CPA2CPA4CMA1 | |
| SCHEMBL7144589 | 0.92 | CTSB (0.61) | CTSBCPA1CPA2CPA4CMA1 | |
| SCHEMBL24178167 | 0.91 | CPA1 (0.52) | CTSBACECPA1CPA2CPA4 | |
| SCHEMBL4325541 | 0.85 | PSMB5 (0.51) | CTSBOPRD1OPRM1FOLH1PSMB5 | |
| SCHEMBL4325539 | 0.85 | PSMB5 (0.51) | CTSBOPRD1OPRM1FOLH1PSMB5 | |
| SCHEMBL6248305 | 0.85 | CTSB (0.55) | CTSBCPA1CPA2CPA4CMA1 | |
| SCHEMBL24178269 | 0.85 | PTPN1 (0.49) | CTSBCPA1CPA2CPA4CTSL | |
| SCHEMBL24178271 | 0.85 | PTPN1 (0.49) | CTSBCPA1CPA2CPA4CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912742-B2 | Heterologous production of leupeptin protease inhibitors and analogs thereof | YALE UNIVERSITY (US) | 2024-02-27 | — | — | US | disclosed |
| US-20220002354-A1 | HETEROLOGOUS PRODUCTION OF LEUPEPTIN PROTEASE INHIBITORS AND ANALOGS THEREOF | YALE UNIVERSITY | 2022-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912742-B2 | Heterologous production of leupeptin protease inhibitors and analogs thereof | LPXN, LAP3, PEPD | CTSB 25/4885ACE 188/4885OPRD1 4256/4885 |
| US-20220002354-A1 | HETEROLOGOUS PRODUCTION OF LEUPEPTIN PROTEASE INHIBITORS AND ANALOGS THEREOF | LPXN, LAP3, PEPD | CTSB 25/4885ACE 188/4885OPRD1 4256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.