Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CPA1 | P15085 | 2/20 | 0.55 |
| ▸ | CPA2 | P48052 | 2/20 | 0.55 |
| ▸ | CPA4 | Q9UI42 | 2/20 | 0.55 |
| ▸ | CPB1 | P15086 | 1/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.55 |
| ▸ | MME | P08473 | 2/20 | 0.53 |
| ▸ | CMA1 | P23946 | 1/20 | 0.53 |
| ▸ | CTRC | Q99895 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.51 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.51 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13706577 | 1.00 | CTSB (0.61) | CTSBALDH1A1CPA1CPA2CPA4 | |
| SCHEMBL24178174 | 0.98 | CTSB (0.58) | CTSBALDH1A1CPA1CPA2CPA4 | |
| SCHEMBL24178168 | 0.98 | CTSB (0.58) | CTSBALDH1A1CPA1CPA2CPA4 | |
| SCHEMBL24178166 | 0.92 | CTSB (0.56) | CTSBALDH1A1CPA1CPA2CPA4 | |
| SCHEMBL6248305 | 0.92 | CTSB (0.55) | CTSBALDH1A1CPA1CPA2CPA4 | |
| SCHEMBL24178171 | 0.90 | CTSB (0.52) | CTSBALDH1A1CPA1CPA2CPA4 | |
| SCHEMBL24178183 | 0.90 | CTSB (0.52) | CTSBALDH1A1CPA1CPA2CPA4 | |
| SCHEMBL5572956 | 0.90 | CTSB (0.63) | CTSBMMECMA1CTRCCTSL | |
| SCHEMBL20204723 | 0.90 | CTSB (0.63) | CTSBMMECMA1CTRCCTSL | |
| SCHEMBL20204725 | 0.90 | CTSB (0.63) | CTSBMMECMA1CTRCCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611756-B1 | Alcohol or aldehyde derivatives as cathepsin L inhibitor and bone resorption inhibitor | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-07 | — | — | EP | disclosed |
| US-5955491-A | ADMINISTERING CATHEPSIN L INHIBITOR AND BONE RESORPTION INHIBITOR CONTAINING AN ALCOHOL OR ALDEHYDE DERIVATIVE, OR SALT THEREOF | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-09-21 | — | — | US | disclosed |
| US-5716980-A | PROPHYLACTIC, THERAPY FOR OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| US-5639781-A | PREVENT REABSORPTION OF BONE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| US-5498728-A | OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-12 | — | — | US | disclosed |
| EP-0611756-A2 | Alcohol or aldehyde derivatives as cathepsin L inhibitor and bone resorption inhibitor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-08-24 | — | — | EP | disclosed |