Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 12/20 | 0.69 |
| ▸ | IGF1R | P08069 | 12/20 | 0.69 |
| ▸ | ALK | Q9UM73 | 12/20 | 0.69 |
| ▸ | EGFR | P00533 | 9/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | CD74 | P04233 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | FES | P07332 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | YES1 | P07947 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25450645 | 0.93 | INSR (0.59) | INSRIGF1RALKEGFRPLK1 | |
| SCHEMBL24178921 | 0.93 | INSR (0.60) | INSRIGF1RALKEGFRCHEK1 | |
| SCHEMBL27360981 | 0.92 | ALK (0.77) | INSRIGF1RALKEGFRCHEK1 | |
| SCHEMBL25449097 | 0.91 | EGFR (0.67) | INSRIGF1RALKEGFRCHEK1 | |
| SCHEMBL30216900 | 0.91 | EGFR (0.67) | INSRIGF1RALKEGFRCHEK1 | |
| SCHEMBL23154320 | 0.90 | ALK (0.76) | INSRIGF1RALKEGFRCHEK1 | |
| SCHEMBL24178908 | 0.89 | ALK (0.56) | INSRIGF1RALKEGFRPLK1 | |
| SCHEMBL25449395 | 0.88 | ALK (0.61) | INSRIGF1RALKEGFR | |
| SCHEMBL24179375 | 0.88 | EGFR (0.58) | INSRIGF1RALKEGFRCHEK1 | |
| SCHEMBL22942149 | 0.88 | INSR (0.69) | INSRIGF1RALKEGFRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4177258-A1 | ARYLPHOSPHINE OXIDE COMPOUNDS AND USE THEREOF | Chengdu Di'Ao Jiuhong Pharmaceutical Factory (CN) | 2023-05-10 | — | — | EP | disclosed |
| WO-2022002241-A1 | ARYLPHOSPHINE OXIDE COMPOUNDS AND USE THEREOF | 成都地奥九泓制药厂 | 2022-01-06 | — | — | WO | disclosed |