Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 4/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.38 |
| ▸ | GUSB | P08236 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31288988 | 0.75 | ALDH1A1 (0.49) | KDM4EALDH1A1NPC1RAB9AGPR55 | |
| SCHEMBL24188484 | 0.72 | HSD11B1 (0.41) | ALDH1A1NPC1RAB9APTGESHPGD | |
| SCHEMBL24187953 | 0.71 | PDCD1 (0.62) | KDM4EALDH1A1NPC1RAB9AGPR55 | |
| SCHEMBL24188144 | 0.70 | GUSB (0.47) | KDM4EALDH1A1NPC1RAB9AGPR55 | |
| SCHEMBL24188483 | 0.69 | HSD11B1 (0.41) | KDM4EALDH1A1PTGESCYP1A2CYP3A4 | |
| SCHEMBL24188247 | 0.69 | PDCD1 (0.49) | KDM4EALDH1A1NPC1RAB9AGPR55 | |
| SCHEMBL30212993 | 0.68 | PDCD1 (0.31) | KDM4EALDH1A1NPC1RAB9AGPR55 | |
| SCHEMBL31288993 | 0.68 | KDR (0.35) | KDM4EALDH1A1NPC1RAB9AGPR55 | |
| SCHEMBL20010988 | 0.66 | SUV39H2 (0.40) | ALDH1A1NPC1RAB9AMAPK14CRBN | |
| SCHEMBL24188365 | 0.66 | KDM4E (0.40) | KDM4EALDH1A1NPC1RAB9AGPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220009935-A1 | INHIBITORS OF GLI1 AS THERAPEUTIC AGENTS | NEW YORK UNIVERSITY | 2022-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220009935-A1 | INHIBITORS OF GLI1 AS THERAPEUTIC AGENTS | GLI1, GLI2, SHH | KDM4E 530/4885ALDH1A1 1281/4885NPC1 488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.