Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HPRT1 | P00492 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746520 | 0.82 | ADORA2A (0.43) | ALDH1A1HSD17B10CYP3A4KDM4ETDP1 | |
| SCHEMBL688993 | 0.79 | ALDH1A1 (0.46) | ALDH1A1HSD17B10TSHRCYP3A4HPGD | |
| SCHEMBL3246612 | 0.79 | ALDH1A1 (0.46) | ALDH1A1HSD17B10TSHRCYP3A4HPGD | |
| SCHEMBL11845980 | 0.78 | ALDH1A1 (0.44) | ALDH1A1HSD17B10TSHRCYP3A4HPGD | |
| SCHEMBL646163 | 0.77 | CA1 (0.52) | ALDH1A1HSD17B10TSHRCYP3A4HPGD | |
| SCHEMBL5251870 | 0.75 | CYP1A2 (0.54) | ALDH1A1HSD17B10TSHRCYP3A4HPGD | |
| SCHEMBL7306027 | 0.75 | CA1 (0.47) | ALDH1A1HSD17B10TSHRCYP3A4HPGD | |
| SCHEMBL5251868 | 0.75 | ALDH1A1 (0.48) | ALDH1A1HSD17B10TSHRCYP3A4HPGD | |
| SCHEMBL1855575 | 0.75 | ESR1 (0.54) | ALDH1A1HSD17B10TSHRHPGDKDM4E | |
| SCHEMBL1392608 | 0.75 | ALDH1A1 (0.45) | ALDH1A1HSD17B10TSHRCYP3A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260109709-A1 | 2-AMINO IMIDAZOLE DERIVATIVES AS PRMT5 INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2026-04-23 | — | — | US | disclosed |
| CN-118974035-A | 2-Aminoimidazole derivatives as PRMT5 inhibitors | 米拉蒂医疗股份有限公司 | 2024-11-15 | — | — | CN | disclosed |
| US-20240368153-A1 | Aminopyridine-based MTA-Cooperative PRMT5 Inhibitors | Mirati Therapeutics, Inc. | 2024-11-07 | — | — | US | disclosed |
| EP-4426690-A2 | 2-AMINO IMIDAZOLE DERIVATIVES AS PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2024-09-11 | — | — | EP | disclosed |
| WO-2023081367-A2 | 2-AMINO IMIDAZOLE DERIVATIVES | Mirati Therapeutics, Inc. (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023081367-A2 | 2-AMINO IMIDAZOLE DERIVATIVES | Mirati Therapeutics, Inc. (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023278564-A1 | AMINOPYRIDINE-BASED MTA-COOPERATIVE PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-01-05 | — | — | WO | disclosed |
| CN-110115365-A | The adjusting that actinism receptor and relative ligand are carried out | 西诺米克斯公司 | 2019-08-13 | — | — | CN | disclosed |
| EP-2573559-B1 | Modulation of chemosensory receptors and ligands associated therewith | SENOMYX INC (US) | 2019-03-13 | — | — | EP | disclosed |
| CN-101779124-B | Modulation of chemosensory receptors and ligands associated therewith | 西诺米克斯公司 | 2017-12-12 | — | — | CN | disclosed |
| EP-0619297-B1 | Fungicides for the control of take-all desease of plants | MONSANTO CO (US) | 1997-06-18 | — | — | EP | disclosed |
| EP-0368212-B1 | Herbicidal agents containing 2-(4-heteroaryloxy) or 2-(4-aryloxy) phenoxy-acetic or propionic acid and/or cyclohexenone derivatives as active ingredients and naphthalene derivatives as antidotes | BASF AG (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0619297-A1 | Fungicides for the control of take-all desease of plants | MONSANTO COMPANY (US) | 1994-10-12 | — | — | EP | disclosed |
| EP-0456090-B1 | Herbicidal agents containing cyclohexenone derivatives as active ingredients and naphthalene derivatives as antidotes | BASF AG (DE) | 1994-07-13 | — | — | EP | disclosed |
| US-5272171-A | Phosphonooxy and carbonate derivatives of taxol | BRISTOL-MYERS SQUIBB COMPANY (US) | 1993-12-21 | — | — | US | disclosed |
| WO-1993017998-A1 | A PROCESS FOR MAKING 2-AMINO-3-METHYL-1-NAPHTHALENECARBONITRILE | THE DOW CHEMICAL COMPANY (US) | 1993-09-16 | — | — | WO | disclosed |
| US-5194658-A | Process for making 2-amino-3-methyl-1-naphthalenecarbonitrile | THE DOW CHEMICAL COMPANY (US) | 1993-03-16 | — | — | US | disclosed |
| EP-0456090-A2 | Herbicidal agents containing cyclohexenone derivatives as active ingredients and naphthalene derivatives as antidotes | BASF Aktiengesellschaft (DE) | 1991-11-13 | — | — | EP | disclosed |
| US-5035736-A | Plant safening agents | BASF AKTIENGESELLSCHAFT (DE) | 1991-07-30 | — | — | US | disclosed |
| EP-0368212-A2 | Herbicidal agents containing 2-(4-heteroaryloxy) or 2-(4-aryloxy) phenoxy-acetic or propionic acid and/or cyclohexenone derivatives as active ingredients and naphthalene derivatives as antidotes | BASF Aktiengesellschaft (DE) | 1990-05-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260109709-A1 | 2-AMINO IMIDAZOLE DERIVATIVES AS PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT3 | ALDH1A1 4159/4885HSD17B10 2933/4885TSHR 1646/4885 |
| US-20240368153-A1 | Aminopyridine-based MTA-Cooperative PRMT5 Inhibitors | PRMT5, PRMT1, PRMT3 | ALDH1A1 3597/4885HSD17B10 4277/4885TSHR 4391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.