Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Foscarnet. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 7/20 | 0.37 |
| ▸ | MMP8 | P22894 | 5/20 | 0.37 |
| ▸ | MMP3 | P08254 | 4/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 4/20 | 0.32 |
| ▸ | MMP9 | P14780 | 3/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | PEPD | P12955 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Foscarnet SCHEMBL23633 | 0.95 | — | — | |
| Foscarnet SCHEMBL15531347 | 0.95 | BLM (0.41) | BLMTDP1MEN1LMNAHPGD | |
| Foscarnet SCHEMBL8647698 | 0.95 | BLM (0.41) | BLMTDP1MEN1LMNAHPGD | |
| Foscarnet SCHEMBL8169999 | 0.91 | BLM (0.39) | BLMTDP1MEN1LMNAHPGD | |
| Foscarnet SCHEMBL8863102 | 0.91 | BLM (0.39) | BLMTDP1MEN1LMNAHPGD | |
| Foscarnet SCHEMBL4538550 | 0.91 | — | — | |
| Foscarnet SCHEMBL5058619 | 0.91 | BLM (0.39) | BLMTDP1MEN1LMNAHPGD | |
| Foscarnet SCHEMBL8854374 | 0.91 | — | — | |
| Foscarnet SCHEMBL7249084 | 0.91 | — | — | |
| Foscarnet SCHEMBL4541599 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230448-A1 | Treatment and/or Prevention of Non-Viral Epithelial Damage | EPISTEM LIMITED (GB) | 2011-09-22 | — | — | US | disclosed |
| US-20100113398-A1 | Treatment and/or Prevention of Non-Viral Epithelial Damage | EPISTEM LIMITED (GB) | 2010-05-06 | — | — | US | disclosed |
| US-20060166941-A1 | Treatment and/or prevention of non-viral epithelial damage | EPISTEM LIMITED (GB) | 2006-07-27 | — | — | US | disclosed |
| EP-1603542-A1 | TREATMENT AND/OR PREVENTION OF NON-VIRAL EPITHELIAL DAMAGE | EPISTEM LIMITED (GB) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004080443-A1 | TREATMENT AND/OR PREVENTION OF NON-VIRAL EPITHELIAL DAMAGE | EPISTEM LIMITED (GB) | 2004-09-23 | — | — | WO | disclosed |