Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 3/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | KRAS | P01116 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24195984 | 0.82 | MAP4K4 (0.51) | MAP4K4CKS1BSKP1SKP2ALK | |
| SCHEMBL24196359 | 0.78 | AR (0.42) | ALDH1A1GAA | |
| SCHEMBL24195787 | 0.77 | SMO (0.47) | SMOALDH1A1KRASSOS1CYP11B1 | |
| SCHEMBL21262379 | 0.77 | AR (0.44) | ALDH1A1GAACYP1A2 | |
| SCHEMBL24195788 | 0.77 | GRIN2D (0.35) | SMOALDH1A1GAA | |
| SCHEMBL21780690 | 0.76 | SMO (0.57) | SMOMAP4K4ALDH1A1GAAHSD17B10 | |
| SCHEMBL24195960 | 0.75 | CASP6 (0.45) | SMOMAP4K4ALDH1A1GAAHSD17B10 | |
| SCHEMBL24196298 | 0.75 | KRAS (0.43) | KRASSOS1CYP11B2 | |
| SCHEMBL20804512 | 0.75 | ALDH1A1 (0.56) | MAP4K4ALDH1A1GAAHSD17B10L3MBTL1 | |
| SCHEMBL736846 | 0.75 | CASP6 (0.59) | SMOMAP4K4ALDH1A1GAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022011274-A1 | SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 | GOLDFINCH BIO, INC. (US) | 2022-01-13 | — | — | WO | disclosed |