Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.52 |
| ▸ | HTR3B | O95264 | 5/20 | 0.52 |
| ▸ | HTR3A | P46098 | 5/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.52 |
| ▸ | HTR6 | P50406 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | HTR7 | P34969 | 3/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL596512 | 0.86 | MAPT (0.53) | MAPTRECQLADRB1HTR3EHTR3B | |
| SCHEMBL478208 | 0.83 | ADRB1 (0.57) | MAPTADRB1HTR3EHTR3BHTR3A | |
| SCHEMBL6874430 | 0.83 | S100B (0.61) | MAPTRECQLTHRBTP53HTT | |
| SCHEMBL8071214 | 0.83 | MAPT (0.61) | MAPTRECQLADRB1HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL28512966 | 0.81 | ADRB1 (0.55) | MAPTADRB1HTR3EHTR3BHTR3A | |
| Hydrochloric Acid SCHEMBL30892475 | 0.81 | ADRB1 (0.55) | MAPTADRB1HTR3EHTR3BHTR3A | |
| SCHEMBL24196423 | 0.81 | S100B (0.65) | MAPTRECQLTHRBTP53HTT | |
| Hydrochloric Acid SCHEMBL8318106 | 0.81 | ADRB1 (0.55) | MAPTADRB1HTR3EHTR3BHTR3A | |
| SCHEMBL24196347 | 0.79 | MAPT (0.40) | MAPTRECQLADRB1HTR3EHTR3B | |
| SCHEMBL14995689 | 0.79 | ADRB1 (0.52) | MAPTADRB1HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022011274-A1 | SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 | GOLDFINCH BIO, INC. (US) | 2022-01-13 | — | — | WO | disclosed |