Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 3/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | PRKCH | P24723 | 1/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | S100B | P04271 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31570658 | 0.86 | MAPT (0.43) | MAPTRECQLGAKDPP4HTR6 | |
| SCHEMBL3125646 | 0.79 | DDB1 (0.46) | MAPTRECQLGAKDPP4PRKCH | |
| SCHEMBL24196401 | 0.79 | MAPT (0.56) | MAPTRECQLHTR6HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL12520575 | 0.78 | AOC3 (0.47) | MAPTHSD11B1AOC3RORCRAB9A | |
| SCHEMBL31570554 | 0.77 | MAPT (0.71) | MAPTRECQLHTR6CYP1A2CYP2C9 | |
| SCHEMBL3315941 | 0.77 | GAK (0.53) | GAKDPP4RAB9AS100BCYP3A4 | |
| SCHEMBL12208591 | 0.76 | HTR3E (0.56) | PKMRORCRAB9AHTR3EHTR3B | |
| SCHEMBL10999344 | 0.75 | CYP2C9 (0.63) | MAPTHTR6PKMHTR3EHTR3B | |
| SCHEMBL5652209 | 0.75 | ALDH1A1 (0.49) | MAPTGAKHSD11B1PRKCHPRKCE | |
| SCHEMBL6874430 | 0.73 | S100B (0.61) | MAPTRECQLPKMRAB9AS100B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022011274-A1 | SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 | GOLDFINCH BIO, INC. (US) | 2022-01-13 | — | — | WO | disclosed |