Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 3/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | USP8 | P40818 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4450143 | 0.83 | TSHR (0.59) | TSHRALOX15KDM4EALDH1A1HPGD | |
| SCHEMBL21022697 | 0.80 | TSHR (0.65) | TSHRHTR1ADRD2HTR7AR | |
| SCHEMBL26014276 | 0.80 | GRIA1 (0.41) | TSHRHTR7GRIA1CACNG8ALDH1A1 | |
| SCHEMBL21022696 | 0.78 | TSHR (0.62) | TSHRHTR1ADRD2HTR7AR | |
| SCHEMBL24196851 | 0.78 | TSHR (0.44) | TSHRHTR1ADRD2HTR7AR | |
| SCHEMBL30269804 | 0.77 | CA2 (0.53) | TSHR | |
| SCHEMBL30270467 | 0.76 | TSHR (0.42) | TSHRGRIA1CACNG8USP8KDM4E | |
| SCHEMBL942 | 0.75 | TSHR (0.46) | TSHRARESR2KDM4EALDH1A1 | |
| SCHEMBL24196740 | 0.75 | AR (0.47) | ARTRPV4EGLN2 | |
| SCHEMBL21189090 | 0.74 | TSHR (0.47) | TSHRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022008475-A1 | INDOLE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER | UNIVERSITE CLAUDE BERNARD LYON 1 (FR) | 2022-01-13 | — | — | WO | disclosed |