Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.43 |
| ▸ | PI4KA | P42356 | 3/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24197146 | 1.00 | YTHDC1 (0.55) | YTHDC1ADORA2ACDK2CCNA2CDK5 | |
| SCHEMBL24197229 | 1.00 | YTHDC1 (0.55) | YTHDC1ADORA2ACDK2CCNA2CDK5 | |
| SCHEMBL26255163 | 0.88 | YTHDC1 (0.53) | YTHDC1ADORA2ACDK2CCNA2CDK5 | |
| SCHEMBL26255190 | 0.84 | YTHDC1 (0.62) | YTHDC1ADORA2ACDK2CCNA2CDK5 | |
| SCHEMBL26255182 | 0.83 | YTHDC1 (0.60) | YTHDC1ADORA2ACDK2CCNA2CDK5 | |
| Hydrochloric Acid SCHEMBL27432783 | 0.80 | YTHDC1 (0.57) | YTHDC1ADORA2ACDK2CCNA2CDK5 | |
| Hydrochloric Acid SCHEMBL27460066 | 0.79 | CDK2 (0.56) | YTHDC1ADORA2ACDK2CCNA2CDK5 | |
| SCHEMBL24197040 | 0.79 | YTHDC1 (0.59) | YTHDC1ADORA2ACDK2CCNA2CDK5 | |
| SCHEMBL26255175 | 0.74 | YTHDC1 (0.59) | YTHDC1ADORA2ACDK2CCNA2CDK5 | |
| SCHEMBL26255189 | 0.74 | YTHDC1 (0.66) | YTHDC1ADORA2ACDK2ADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240189278-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLOTHO THERAPEUTICS, INC. | 2024-06-13 | — | — | US | disclosed |
| US-20230279006-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLOTHO THERAPEUTICS, INC. | 2023-09-07 | — | — | US | disclosed |
| US-20230279006-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLOTHO THERAPEUTICS, INC. | 2023-09-07 | — | — | US | disclosed |
| US-20230279006-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLOTHO THERAPEUTICS, INC. | 2023-09-07 | — | — | US | disclosed |
| WO-2022011171-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLOTHO THERAPEUTICS, INC. (US) | 2022-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240189278-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | COL2A1, COL1A1, COL14A1 | YTHDC1 2682/4885ADORA2A 876/4885CDK2 470/4885 |
| US-20230279006-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLKB1, KLK2, KLK1 | YTHDC1 2838/4885ADORA2A 2475/4885CDK2 2629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.