Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 3/20 | 0.40 |
| ▸ | ACACA | Q13085 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PPID | Q08752 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21438465 | 0.85 | CYP1A2 (0.46) | ACACBACACACYP1A2CYP2C9CYP3A4 | |
| SCHEMBL21439648 | 0.84 | HDAC1 (0.44) | ACACBACACACYP1A2CYP2C9CYP3A4 | |
| SCHEMBL21545151 | 0.78 | ACACB (0.49) | ACACBACACACYP1A2CYP2C9CYP3A4 | |
| SCHEMBL25890795 | 0.76 | BRD4 (0.36) | CFDBRD4PPIDL3MBTL1GLS | |
| SCHEMBL25879822 | 0.76 | CFD (0.48) | CYP1A2CFDNAMPTBRD4L3MBTL1 | |
| SCHEMBL25879573 | 0.75 | GLS (0.37) | ACACBACACACYP1A2CYP2C9CYP3A4 | |
| SCHEMBL21561974 | 0.72 | BRD4 (0.41) | CFDNAMPTBRD4PPIDL3MBTL1 | |
| SCHEMBL23616856 | 0.72 | NAMPT (0.40) | ACACBACACACYP1A2CYP2C9CYP3A4 | |
| SCHEMBL29095074 | 0.72 | BRD4 (0.43) | ACACBACACACYP1A2CYP2C9CYP3A4 | |
| SCHEMBL21438190 | 0.72 | CFD (0.75) | CYP2C9CFDNAMPTBRD4PPID |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939658-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-01-19 | — | — | EP | disclosed |