Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.51 |
| ▸ | ELANE | P08246 | 5/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20158839 | 0.89 | ELANE (0.42) | MAPK8ELANECNR2ALDH1A1PRNP | |
| SCHEMBL20138831 | 0.87 | CNR1 (0.43) | ELANECNR2ALDH1A1POLB | |
| SCHEMBL24200445 | 0.86 | MAPK8 (0.53) | MAPK8ELANEALDH1A1POLBPRNP | |
| SCHEMBL20158832 | 0.78 | MAPK8 (0.49) | MAPK8ELANEALDH1A1 | |
| SCHEMBL20158843 | 0.77 | ELANE (0.43) | ELANECNR2ALDH1A1 | |
| SCHEMBL20138825 | 0.75 | ELANE (0.54) | MAPK8ELANEPRNPPPARGRXFP1 | |
| SCHEMBL20159077 | 0.71 | LMNA (0.55) | ELANEPPARG | |
| SCHEMBL20147125 | 0.71 | P2RX4 (0.50) | ELANEALDH1A1 | |
| SCHEMBL20139087 | 0.67 | ELANE (0.53) | MAPK8ELANEALDH1A1 | |
| SCHEMBL7059986 | 0.67 | CNR2 (0.39) | ELANECNR2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538529-B1 | SELECTIVE INHIBITORS OF GENOTOXIC STRESS-INDUCED IKK/NF-KB PATHWAYS | MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN HELMHOLTZ GEMEINSCHAFT (DE) | 2022-01-19 | — | — | EP | disclosed |