Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | ELANE | P08246 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138825 | 0.88 | ELANE (0.54) | MAPK8ELANEPRNPPPARGRXFP1 | |
| SCHEMBL20158832 | 0.87 | MAPK8 (0.49) | MAPK8ELANEALDH1A1PTGS2 | |
| SCHEMBL24200422 | 0.86 | MAPK8 (0.51) | MAPK8ELANEPOLBPRNPPPARG | |
| SCHEMBL20147125 | 0.85 | P2RX4 (0.50) | ELANEP2RX4ALDH1A1PTGS2PLAU | |
| SCHEMBL20159077 | 0.84 | LMNA (0.55) | ELANEPPARGPTGS2 | |
| SCHEMBL20139087 | 0.76 | ELANE (0.53) | MAPK8ELANEALDH1A1PTGS2 | |
| SCHEMBL20158839 | 0.75 | ELANE (0.42) | MAPK8ELANEPRNPPPARGRXFP1 | |
| SCHEMBL20138831 | 0.74 | CNR1 (0.43) | ELANEPOLBALDH1A1 | |
| SCHEMBL12034344 | 0.73 | P2RX4 (0.61) | ELANEP2RX4ALDH1A1 | |
| SCHEMBL20158841 | 0.73 | ELANE (0.56) | ELANEPPARGPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538529-B1 | SELECTIVE INHIBITORS OF GENOTOXIC STRESS-INDUCED IKK/NF-KB PATHWAYS | MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN HELMHOLTZ GEMEINSCHAFT (DE) | 2022-01-19 | — | — | EP | disclosed |