Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20158911 | 0.77 | KMT2A (0.54) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL20158977 | 0.77 | KDM4E (0.68) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL20158976 | 0.77 | LMNA (0.52) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL20138952 | 0.70 | KMT2A (0.53) | KDM4EALDH1A1HPGDHTTTSHR | |
| SCHEMBL20159028 | 0.67 | KDM4E (0.54) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL24200430 | 0.66 | KDM4E (0.70) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL21341228 | 0.64 | KDM4E (0.45) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL24969968 | 0.64 | MEN1 (0.47) | KDM4EALDH1A1LMNATSHRMAPK1 | |
| SCHEMBL20147149 | 0.64 | MAOA (0.46) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL20147143 | 0.62 | DYRK1A (0.41) | KDM4EALDH1A1HPGDHTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538529-B1 | SELECTIVE INHIBITORS OF GENOTOXIC STRESS-INDUCED IKK/NF-KB PATHWAYS | MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN HELMHOLTZ GEMEINSCHAFT (DE) | 2022-01-19 | — | — | EP | disclosed |