Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22418545 | 0.81 | CDK2 (0.36) | JAK3JAK2PDE10A | |
| SCHEMBL22418617 | 0.75 | JAK2 (0.54) | JAK3JAK2 | |
| SCHEMBL24200601 | 0.70 | EGFR (0.34) | SRC | |
| SCHEMBL26246774 | 0.69 | KDM4E (0.36) | JAK3JAK2SRC | |
| SCHEMBL24200698 | 0.68 | ALDH1A1 (0.36) | — | |
| SCHEMBL22436175 | 0.62 | JAK1 (0.39) | JAK3JAK2SRC | |
| SCHEMBL24509511 | 0.58 | HTR6 (0.45) | — | |
| SCHEMBL24509488 | 0.57 | HTR6 (0.46) | — | |
| SCHEMBL29713733 | 0.57 | HTR6 (0.46) | — | |
| SCHEMBL22436161 | 0.57 | HRH2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939979-A1 | JAK KINASE INHIBITOR, PREPARATION METHOD FOR SAME, AND APPLICATIONS THEREOF IN FIELD OF MEDICINE | Shanghai Synergy Pharmaceutical Sciences Co., Ltd (CN) | 2022-01-19 | — | — | EP | disclosed |