SCHEMBL2420144

SCHEMBL2420144

O=[N+]([O-])c1ccc2oc(S)nc2c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 9/20 0.61
NPC1 O15118 7/20 0.61
SMN1; SMN2 Q16637 3/20 0.61
MAPT P10636 6/20 0.58
MEN1 O00255 3/20 0.58
KMT2A Q03164 3/20 0.58
ALDH1A1 P00352 3/20 0.58
MCL1 Q07820 1/20 0.58
ATM Q13315 1/20 0.58
MMP2 P08253 2/20 0.51
MMP9 P14780 2/20 0.51
MMP8 P22894 2/20 0.51
MMP13 P45452 2/20 0.51
POLB P06746 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.47
DAGLA Q9Y4D2 1/20 0.46
TXNRD1 Q16881 1/20 0.46
TXNRD3 Q86VQ6 1/20 0.46
TXNRD2 Q9NNW7 1/20 0.46
PSMB8 P28062 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29362134 1.00 RAB9A (0.61) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL5155914 0.86 MAPT (0.61) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL11443651 0.83 MEN1 (0.62) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL15172875 0.83 RAB9A (0.61) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL2060733 0.81 ALDH1A1 (0.61) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL10173106 0.81 RAB9A (0.65) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL2244450 0.81 RAB9A (0.60) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL31490986 0.81 RAB9A (0.65) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL10173135 0.81 RAB9A (0.60) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL31430630 0.81 RAB9A (0.60) RAB9ANPC1SMN1; SMN2MAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025071094-A1 USES OF MERCAPTO FUNCTIONAL COMPOUND HAVING TYROSINASE INHIBITORY ACTIVITY 부산대학교 산학협력단 2025-04-03 WO claimed
WO-2025071094-A1 USES OF MERCAPTO FUNCTIONAL COMPOUND HAVING TYROSINASE INHIBITORY ACTIVITY 부산대학교 산학협력단 2025-04-03 WO disclosed
CN-117843579-A Benzo heterocycle coupled catechol derivative and preparation method and application thereof 暨南大学 2024-04-09 CN disclosed
CN-115124485-B Sulfoxide-containing benzoxazole derivative, and preparation method and application thereof 中国医学科学院药物研究所 2023-12-15 CN disclosed
CN-115167076-A Photosensitive resin composition and photosensitive dry film resist laminate 杭州福斯特电子材料有限公司 2022-10-11 CN disclosed
CN-115124485-A Benzoxazole derivatives containing sulfoxide as well as preparation method and application thereof 中国医学科学院药物研究所 2022-09-30 CN disclosed
CN-113185511-B Pyrimidine compound and preparation method and application thereof 中国医学科学院医药生物技术研究所 2022-04-26 CN disclosed
CN-107743483-B NADPH oxidase 4 inhibitors 埃科特莱茵药品有限公司 2022-01-28 CN disclosed
US-20210395238-A1 NADPH OXIDASE 4 INHIBITORS ACTELTION PHARMACEUTICALS LTD (CH) 2021-12-23 US disclosed
US-11136317-B2 NADPH oxidase 4 inhibitors ACTELION PHARMACEUTICALS LTD (CH) 2021-10-05 US disclosed
EP-0442323-A2 Silver halide color reversal photographic material capable of providing interimage effect FUJI PHOTO FILM CO., LTD. (JP) 1991-08-21 EP disclosed
EP-0436027-A1 METHOD OF TREATING SILVER HALIDE PHOTOGRAPHIC MATERIAL FUJI PHOTO FILM CO., LTD. (JP) 1991-07-10 EP disclosed
US-5006444-A Silver halide photographic material FUJI PHOTO FILM CO., LTD. (JP) 1991-04-09 US disclosed
EP-0420005-A1 high contrast silver halide photographic material FUJI PHOTO FILM CO., LTD. (JP) 1991-04-03 EP disclosed
EP-0398285-A2 Silver halide photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1990-11-22 EP disclosed
EP-0395069-A2 Silver halide photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1990-10-31 EP disclosed
EP-0393720-A2 Silver halide photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1990-10-24 EP disclosed
EP-0335319-A2 Silver halide photographic material FUJI PHOTO FILM CO., LTD. (JP) 1989-10-04 EP disclosed
US-4737442-A INCLUDING A SENSITIZER AND A BLOCKED DEVELOPMENT RESTRAINER; FREE OF BLACK SPOTS FUJI PHOTO FILM CO., LTD. (JP) 1988-04-12 US disclosed
US-4234578-A ANTIBIOTICS CIBA-GEIGY CORPORATION (US) 1980-11-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11136317-B2 NADPH oxidase 4 inhibitors NOX4, NOX1, CYBB RAB9A 2128/4885NPC1 3120/4885SMN1; SMN2 3582/4885
US-20210395238-A1 NADPH OXIDASE 4 INHIBITORS NOX4, NOX1, CYBB RAB9A 2128/4885NPC1 3120/4885SMN1; SMN2 3582/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.