Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | F7 | P08709 | 1/20 | 0.31 |
| ▸ | F3 | P13726 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24201459 | 0.86 | TBK1 (0.36) | ALDH1A1HSD17B10LMNAMEN1TP53 | |
| SCHEMBL23030530 | 0.79 | USP2 (0.45) | GAAALDH1A1USP2PKMHPGD | |
| SCHEMBL13284036 | 0.71 | ALDH1A1 (0.42) | GAAALDH1A1USP2PKMHPGD | |
| SCHEMBL16806137 | 0.69 | ALDH1A1 (0.43) | GAAALDH1A1USP2PKMHPGD | |
| SCHEMBL14295015 | 0.68 | ALDH1A1 (0.42) | GAAALDH1A1USP2PKMHPGD | |
| SCHEMBL12386894 | 0.67 | FTO (0.50) | GAAALDH1A1USP2PKMHPGD | |
| SCHEMBL9963713 | 0.66 | AHR (0.47) | GAAALDH1A1USP2PKMHPGD | |
| SCHEMBL21237911 | 0.66 | AHR (0.47) | GAAALDH1A1USP2PKMHPGD | |
| SCHEMBL14072510 | 0.66 | ALDH1A1 (0.40) | GAAALDH1A1USP2PKMHPGD | |
| SCHEMBL12386901 | 0.66 | IGLV6-57 (0.60) | GAAALDH1A1HPGDHSD17B10CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353176-B1 | BICYCLIC COMPOUNDS AS ATX INHIBITORS | HOFFMANN LA ROCHE (CH) | 2022-01-19 | — | — | EP | disclosed |