Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10100725 | 0.85 | DRD2 (0.53) | DRD2DRD4GAAS1PR1KDM4E | |
| SCHEMBL5958650 | 0.80 | DRD2 (0.52) | DRD2DRD4GAAS1PR1KDM4E | |
| SCHEMBL20747804 | 0.79 | DRD2 (0.47) | DRD2DRD4GAAS1PR1KDM4E | |
| SCHEMBL4991137 | 0.78 | PARP10 (0.56) | DRD2DRD4GAAS1PR1PARP1 | |
| SCHEMBL761229 | 0.75 | GAA (0.53) | DRD2DRD4GAAKDM4EMAPT | |
| SCHEMBL19185633 | 0.74 | GAA (0.49) | DRD2DRD4GAAKDM4EMAPT | |
| SCHEMBL11358716 | 0.72 | DRD2 (0.51) | DRD2DRD4GAAS1PR1KDM4E | |
| SCHEMBL24347717 | 0.72 | GAA (0.51) | DRD2DRD4GAAKDM4EMAPT | |
| SCHEMBL11350954 | 0.71 | DRD2 (0.50) | DRD2DRD4GAAS1PR1KDM4E | |
| SCHEMBL12461 | 0.71 | DRD2 (0.59) | DRD2DRD4GAAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939981-A1 | FUSED THIAZOLOPYRIMIDINE DERIVATIVES AS MNKS INHIBITORS | LifeArc (GB) | 2022-01-19 | — | — | EP | disclosed |