Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.42 |
| ▸ | EIF4E | P06730 | 4/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23761571 | 0.95 | MKNK1 (0.48) | MKNK1MKNK2EIF4ESRD5A1NOTUM | |
| SCHEMBL23761440 | 0.91 | MKNK1 (0.53) | MKNK1MKNK2EIF4ENOTUMPIK3CA | |
| SCHEMBL24201711 | 0.89 | MKNK1 (0.44) | MKNK1MKNK2EIF4ESRD5A1NOTUM | |
| SCHEMBL23761361 | 0.83 | MKNK1 (0.39) | MKNK1MKNK2EIF4ESRD5A1NOTUM | |
| SCHEMBL24202017 | 0.80 | NOTUM (0.41) | MKNK1MKNK2EIF4ESRD5A1NOTUM | |
| SCHEMBL23761552 | 0.79 | MKNK1 (0.33) | MKNK1MKNK2EIF4ESRD5A1NOTUM | |
| SCHEMBL23761540 | 0.78 | MKNK1 (0.36) | MKNK1MKNK2EIF4ESRD5A1NOTUM | |
| SCHEMBL24201720 | 0.77 | KMT2A (0.40) | MKNK1MKNK2EIF4ESRD5A1NOTUM | |
| SCHEMBL24201658 | 0.74 | SRD5A1 (0.41) | MKNK1MKNK2EIF4ESRD5A1NOTUM | |
| SCHEMBL23761414 | 0.72 | SRD5A1 (0.45) | MKNK1MKNK2EIF4ESRD5A1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939981-A1 | FUSED THIAZOLOPYRIMIDINE DERIVATIVES AS MNKS INHIBITORS | LifeArc (GB) | 2022-01-19 | — | — | EP | disclosed |