Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.44 |
| ▸ | EIF4E | P06730 | 4/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24202118 | 0.89 | MKNK1 (0.42) | MKNK1MKNK2EIF4ENOTUMPIK3CA | |
| SCHEMBL24201720 | 0.88 | KMT2A (0.40) | MKNK1MKNK2EIF4ENOTUMSMN1; SMN2 | |
| SCHEMBL24202016 | 0.86 | MKNK1 (0.36) | MKNK1MKNK2EIF4ENOTUMPIK3CA | |
| SCHEMBL23761571 | 0.85 | MKNK1 (0.48) | MKNK1MKNK2EIF4ENOTUMPIK3CA | |
| SCHEMBL24202017 | 0.84 | NOTUM (0.41) | MKNK1MKNK2EIF4ENOTUMSMN1; SMN2 | |
| SCHEMBL24202077 | 0.83 | MKNK1 (0.37) | MKNK1MKNK2EIF4ENOTUMSRD5A1 | |
| SCHEMBL23761657 | 0.82 | MKNK1 (0.49) | MKNK1MKNK2EIF4ENOTUMPIK3CA | |
| SCHEMBL23761435 | 0.82 | MKNK1 (0.45) | MKNK1MKNK2EIF4ENOTUM | |
| SCHEMBL23761440 | 0.80 | MKNK1 (0.53) | MKNK1MKNK2EIF4ENOTUMPIK3CA | |
| SCHEMBL24201824 | 0.80 | MKNK1 (0.45) | MKNK1MKNK2EIF4ENOTUMSRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939981-A1 | FUSED THIAZOLOPYRIMIDINE DERIVATIVES AS MNKS INHIBITORS | LifeArc (GB) | 2022-01-19 | — | — | EP | disclosed |