Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2427077 | 0.80 | HDAC6 (0.46) | HDAC6SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL2424150 | 0.79 | ALDH1A1 (0.49) | TRPM8HDAC6SMN1; SMN2NPC1RAB9A | |
| SCHEMBL20486119 | 0.79 | NPC1 (0.54) | HDAC6SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL27768576 | 0.77 | NPC1 (0.51) | HDAC6SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL8840161 | 0.77 | NPC1 (0.51) | HDAC6SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL20486565 | 0.75 | ALDH1A1 (0.45) | TRPM8HDAC6SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2428586 | 0.74 | ALDH1A1 (0.44) | TRPM8NR1H4HDAC6SMN1; SMN2NPC1 | |
| SCHEMBL191761 | 0.74 | NPC1 (0.49) | HDAC6SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL11233145 | 0.74 | NPC1 (0.49) | HDAC6SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL2423066 | 0.73 | NPC1 (0.49) | TRPM8HDAC6SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605752-B1 | Sulfonamides for the treatment of congestive heart failure, their compositions and uses. | CYTOKINETICS INC (US) | 2011-09-14 | — | — | EP | disclosed |