Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 8/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | TAF1 | P21675 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3341729 | 0.81 | GAA (0.42) | GAAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL22306339 | 0.81 | GAA (0.45) | GAAKDM4EBRD4PTPN1BRD9 | |
| SCHEMBL24207556 | 0.80 | GAA (0.41) | GAABRD4ATAD2BRD9MTNR1A | |
| SCHEMBL30369590 | 0.78 | CYP3A4 (0.39) | GAAKDM4EALDH1A1GLAHPGD | |
| SCHEMBL24207729 | 0.77 | GAA (0.40) | GAABRD4ATAD2BRD9MTNR1A | |
| SCHEMBL564816 | 0.76 | GAA (0.56) | GAAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30098515 | 0.76 | GAA (0.56) | GAAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9400494 | 0.75 | DHFR (0.45) | GAAKDM4EALDH1A1GLAHPGD | |
| SCHEMBL31036090 | 0.75 | DHFR (0.45) | GAAKDM4EALDH1A1GLAHPGD | |
| SCHEMBL24207796 | 0.71 | ALDH1A1 (0.39) | GAAKDM4EALDH1A1GLAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022012622-A1 | DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2022-01-20 | — | — | WO | disclosed |