Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TERT | O14746 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346154 | 0.81 | KDM4E (0.42) | CYP2C19CYP1A2CYP2D6CYP2C9RXFP1 | |
| SCHEMBL22951342 | 0.77 | NR4A2 (0.40) | CYP2C19KDM4ECYP3A4HIF1AIDO1 | |
| SCHEMBL24207416 | 0.76 | IDO1 (0.35) | CYP2C19KDM4ECYP3A4HIF1AIDO1 | |
| SCHEMBL25083068 | 0.73 | IMPDH2 (0.42) | CYP2C19CYP1A2KDM4ECYP3A4HIF1A | |
| SCHEMBL22951353 | 0.73 | IDO1 (0.38) | CYP2C19CYP1A2KDM4ECYP3A4HIF1A | |
| SCHEMBL24743148 | 0.71 | IDO1 (0.34) | CYP2C19CYP1A2KDM4ECYP3A4HIF1A | |
| SCHEMBL1464159 | 0.70 | MAPT (0.59) | CYP1A2KDM4ECYP3A4HIF1AIDO1 | |
| SCHEMBL22950952 | 0.70 | IDO1 (0.33) | CYP2C19CYP1A2KDM4ECYP3A4HIF1A | |
| SCHEMBL1474541 | 0.70 | DHFR (0.40) | CYP1A2CYP2D6CYP2C9KDM4ECYP3A4 | |
| SCHEMBL29364256 | 0.70 | DHFR (0.40) | CYP1A2CYP2D6CYP2C9KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022012622-A1 | DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2022-01-20 | — | — | WO | disclosed |