Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1758 | 0.91 | HDAC4 (0.51) | HSD11B1HDAC4MEN1KMT2ANCOA1 | |
| SCHEMBL2436168 | 0.84 | AKR1C1 (0.51) | HDAC4MEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL2550 | 0.84 | HDAC4 (0.54) | HSD11B1HDAC4NCOA1SMN1; SMN2CHRM2 | |
| SCHEMBL13267655 | 0.80 | HDAC4 (0.57) | HSD11B1HDAC4SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL10791058 | 0.79 | HSD17B3 (0.51) | MEN1KMT2ASMN1; SMN2CHRM2ALDH1A1 | |
| SCHEMBL10787888 | 0.79 | KMT2A (0.48) | HSD11B1HDAC4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1770373 | 0.79 | HDAC4 (0.56) | HSD11B1HDAC4NCOA1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3443916 | 0.79 | HDAC4 (0.56) | HSD11B1HDAC4NCOA1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10790545 | 0.78 | MEN1 (0.47) | MEN1KMT2ASMN1; SMN2CHRM2NPSR1 | |
| SCHEMBL10787474 | 0.78 | MEN1 (0.47) | MEN1KMT2ASMN1; SMN2CHRM2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4814352-A | ANTIDEPRESSANT CYCLOBUTYL BENZYLAMINE | THE BOOTS COMPANY PLC (GB) | 1989-03-21 | — | — | US | disclosed |
| US-4806570-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1989-02-21 | — | — | US | disclosed |
| US-4767790-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1988-08-30 | — | — | US | disclosed |
| US-4746680-A | ANTIDEPRESSANTS | THE BOOTS COMPANY P.L.C. (GB) | 1988-05-24 | — | — | US | disclosed |