Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 9/20 | 0.54 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13267655 | 0.95 | HDAC4 (0.57) | HDAC4HSD11B1SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL13545175 | 0.93 | HSD11B1 (0.51) | HDAC4HSD11B1SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL1758 | 0.87 | HDAC4 (0.51) | HDAC4HSD11B1NCOA1SMN1; SMN2CHRM2 | |
| SCHEMBL684441 | 0.85 | DRD2 (0.51) | HDAC4HSD11B1SMN1; SMN2OPRM1ALDH1A1 | |
| SCHEMBL1770373 | 0.84 | HDAC4 (0.56) | HDAC4HSD11B1NCOA1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3443916 | 0.84 | HDAC4 (0.56) | HDAC4HSD11B1NCOA1SMN1; SMN2ALDH1A1 | |
| SCHEMBL684695 | 0.84 | OPRM1 (0.67) | HSD11B1OPRM1 | |
| SCHEMBL2421 | 0.84 | HSD11B1 (0.49) | HDAC4HSD11B1NCOA1SMN1; SMN2CHRM2 | |
| SCHEMBL8225678 | 0.83 | HDAC4 (0.54) | HDAC4HSD11B1NCOA1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1769960 | 0.83 | HDAC4 (0.54) | HDAC4HSD11B1SMN1; SMN2CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101952275-B | Modulators for amyloid protein beta | HOFFMANN LA ROCHE | 2014-06-18 | — | — | CN | disclosed |
| CN-101952275-A | Modulators for amyloid beta | HOFFMANN LA ROCHE | 2011-01-19 | — | — | CN | disclosed |
| CN-101573334-A | Multi-mediator transporter inhibitors for the treatment of central nervous system disorders | PREXA PHARMACEUTICALS INC (US) | 2009-11-04 | — | — | CN | disclosed |
| CN-1255136-A | Substituted 4-arylmethylene-2-imino-2,3-dihydrothiazoles and derivatives and their pharmaceutical use | KNOLL AG (DE) | 2000-05-31 | — | — | CN | disclosed |
| CN-1012733-B | Process for the preparation of therapeutic agents | BOOTS CO PLC (GB) | 1991-06-05 | — | — | CN | disclosed |
| US-4814352-A | ANTIDEPRESSANT CYCLOBUTYL BENZYLAMINE | THE BOOTS COMPANY PLC (GB) | 1989-03-21 | — | — | US | disclosed |
| US-4806570-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1989-02-21 | — | — | US | disclosed |
| US-4767790-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1988-08-30 | — | — | US | disclosed |
| US-4746680-A | ANTIDEPRESSANTS | THE BOOTS COMPANY P.L.C. (GB) | 1988-05-24 | — | — | US | disclosed |
| CN-86100954-A | The preparation method of therapeutical agent and application | — | 1986-09-03 | — | — | CN | disclosed |
| US-4522828-A | CYCLOBUTYLALKYLAMINE COMPOUNDS, ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1985-06-11 | — | — | US | disclosed |