Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 16/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.44 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.40 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16071435 | 0.79 | FGFR4 (0.77) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL19069263 | 0.77 | FGFR4 (0.42) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL21860422 | 0.75 | FGFR4 (0.49) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL24225216 | 0.73 | FGFR4 (0.49) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL23653399 | 0.73 | EGFR (0.57) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL23653276 | 0.72 | EGFR (0.44) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL24224962 | 0.72 | FGFR4 (0.56) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL21166367 | 0.72 | FGFR4 (0.62) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL16071425 | 0.71 | FGFR4 (0.69) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL28640666 | 0.70 | FGFR4 (0.72) | FGFR4FGFR1FGFR2FGFR3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3943087-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | Celgene CAR LLC (BM) | 2022-01-26 | — | — | EP | disclosed |