Sugi Predict

Sugi Predict / Compounds / SCHEMBL2422907

SCHEMBL2422907

SCHEMBL2422907

CC(O)Cc1c(F)cccc1F

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 1/20 0.38
▸ ALDH1A1 P00352 3/20 0.37
▸ KDM4E B2RXH2 3/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ TAAR1 Q96RJ0 1/20 0.36
▸ HPGD P15428 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ GABRA1 P14867 2/20 0.35
▸ GABRG2 P18507 1/20 0.35
▸ GABRB3 P28472 1/20 0.35
▸ GABRB2 P47870 1/20 0.35
▸ CES2 O00748 2/20 0.35
▸ CES1 P23141 2/20 0.35
▸ DPP4 P27487 1/20 0.35
▸ CYP3A4 P08684 1/20 0.34
▸ SLC6A2 P23975 1/20 0.33
▸ SLC6A4 P31645 1/20 0.33
▸ BACE1 P56817 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2428955 0.86 GAA (0.53) GAAALDH1A1KDM4ESMN1; SMN2TAAR1
SCHEMBL30116829 0.86 EED (0.38) GAAALDH1A1KDM4ESMN1; SMN2TAAR1
SCHEMBL2427582 0.85 SLC6A2 (0.46) TAAR1CYP3A4SLC6A2SLC6A4
SCHEMBL170907 0.81 GABRA1 (0.43) GAAALDH1A1KDM4ESMN1; SMN2TAAR1
SCHEMBL18400702 0.77 KDM4E (0.39) GAAALDH1A1KDM4ESMN1; SMN2TAAR1
SCHEMBL14478256 0.77 SLC6A2 (0.52) TAAR1SLC6A2SLC6A4
SCHEMBL27565475 0.77 GABRA1 (0.41) ALDH1A1GABRA1GABRB2CES2CES1
SCHEMBL6203911 0.77 SMN1; SMN2 (0.36) GAAALDH1A1KDM4ESMN1; SMN2TAAR1
SCHEMBL15082795 0.76 TAAR1 (0.45) ALDH1A1TAAR1GABRA1GABRB2CYP3A4
SCHEMBL14718937 0.76 TAAR1 (0.45) ALDH1A1TAAR1GABRA1GABRB2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2265616-B1 FURO-AND THIENO[3,2-C]PYRIDINES OSI PHARM INC (US) 2013-11-20 — — EP disclosed
US-8022206-B2 Furo[3,2-C]pyridines OSI Pharmaceuticals, LLC (US) 2011-09-20 — — US disclosed
US-8022206-B2 Furo[3,2-C]pyridines OSI Pharmaceuticals, LLC (US) 2011-09-20 — — US disclosed
US-8022206-B2 Furo[3,2-C]pyridines OSI Pharmaceuticals, LLC (US) 2011-09-20 — — US disclosed
EP-2265616-A1 FURO-AND THIENO[3,2-C]PYRIDINES OSI Pharmaceuticals, Inc. (US) 2010-12-29 — — EP disclosed
WO-2009100282-A1 FURO-AND THIENO[3,2-C] PYRIDINES OSI PHARMACEUTICALS, INC. (US) 2009-08-13 — — WO disclosed
WO-2009100282-A1 FURO-AND THIENO[3,2-C] PYRIDINES OSI PHARMACEUTICALS, INC. (US) 2009-08-13 — — WO disclosed
US-20090197864-A1 Furo- and Thieno [3,2-c] Pyridines OSI PHARMACEUTICALS, INC. 2009-08-06 — — US disclosed
US-20090197864-A1 Furo- and Thieno [3,2-c] Pyridines OSI PHARMACEUTICALS, INC. 2009-08-06 — — US disclosed
US-20090197864-A1 Furo- and Thieno [3,2-c] Pyridines OSI PHARMACEUTICALS, INC. 2009-08-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090197864-A1 Furo- and Thieno [3,2-c] Pyridines RET, MET, ERBB2 GAA 4554/4885ALDH1A1 589/4885KDM4E 1230/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.