Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 2/20 | 0.33 |
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201421 | 0.78 | IDO1 (0.42) | ALDH1A1KDM4ESLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9729259 | 0.78 | SMN1; SMN2 (0.35) | SMN1; SMN2GAAALDH1A1KDM4ESLC6A2 | |
| SCHEMBL2422907 | 0.77 | GAA (0.38) | SMN1; SMN2GAAALDH1A1KDM4ESLC6A2 | |
| SCHEMBL6203907 | 0.76 | SMN1; SMN2 (0.36) | SMN1; SMN2GAAALDH1A1KDM4ESLC6A2 | |
| SCHEMBL6204367 | 0.76 | AKR1B1 (0.39) | SMN1; SMN2GAAALDH1A1KDM4ESLC6A2 | |
| SCHEMBL25440547 | 0.74 | — | — | |
| SCHEMBL6204388 | 0.72 | SLC1A1 (0.46) | TAAR1 | |
| SCHEMBL170907 | 0.72 | GABRA1 (0.43) | SMN1; SMN2GAAALDH1A1KDM4ESLC6A2 | |
| SCHEMBL10058270 | 0.71 | GAA (0.37) | SMN1; SMN2GAAALDH1A1KDM4EKMT2A | |
| SCHEMBL6205902 | 0.69 | TRPA1 (0.50) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |