Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24229266 | 0.89 | PBRM1 (0.45) | HSD17B1AKR1B1MAPK14MAOAMAOB | |
| SCHEMBL6227273 | 0.82 | AKR1B1 (0.49) | CASP1CASP7HSD17B10HSD17B1AKR1B1 | |
| SCHEMBL4817434 | 0.77 | CASP1 (0.50) | CASP1CASP7HSD17B10HSD17B1AKR1B1 | |
| SCHEMBL28144985 | 0.76 | CASP1 (0.53) | CASP1CASP7HSD17B10HSD17B1AKR1B1 | |
| SCHEMBL27717299 | 0.75 | MAPT (0.46) | CASP1CASP7HSD17B10HSD17B1AKR1B1 | |
| SCHEMBL22912848 | 0.75 | CASP1 (0.49) | CASP1CASP7HSD17B10HSD17B1AKR1B1 | |
| SCHEMBL8099995 | 0.75 | ALDH1A1 (0.54) | CASP1CASP7HSD17B10HSD17B1ACACB | |
| SCHEMBL86398 | 0.74 | CASP1 (0.47) | CASP1CASP7HSD17B10HSD17B1AKR1B1 | |
| SCHEMBL27717447 | 0.74 | CASP1 (0.47) | CASP1CASP7HSD17B10HSD17B1ACACB | |
| SCHEMBL4805957 | 0.73 | CASP1 (0.53) | CASP1CASP7HSD17B10HSD17B1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022023460-A1 | ACRYLAMIDE-SUBSTITUTED INDANE COMPOUNDS AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2022-02-03 | — | — | WO | disclosed |