Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 3/20 | 0.54 |
| ▸ | GABRD | O14764 | 3/20 | 0.54 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.54 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.54 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.54 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.54 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.54 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.54 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.54 |
| ▸ | GABRE | P78334 | 3/20 | 0.54 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.54 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.54 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.54 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperidine SCHEMBL2420535 | 0.91 | GABRP (0.48) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2422767 | 0.90 | GABRP (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL19466558 | 0.78 | GABRP (0.38) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Piperazine SCHEMBL1900242 | 0.76 | TSHR (0.79) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Isonipecotic Acid SCHEMBL23043998 | 0.74 | TSHR (0.94) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Isonipecotic Acid SCHEMBL104297 | 0.71 | — | — | |
| Isonipecotic Acid SCHEMBL2027408 | 0.71 | TSHR (1.00) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Isonipecotic Acid SCHEMBL5035880 | 0.69 | TSHR (0.94) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Isonipecotic Acid SCHEMBL6122239 | 0.69 | TSHR (0.94) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Isonipecotic Acid SCHEMBL1703706 | 0.69 | TSHR (0.94) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367817-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | Via Pharmaceuticals, Inc. (US) | 2011-09-28 | — | — | EP | claimed |
| WO-2010065310-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | VIA PHARMACEUTICALS, INC (US) | 2010-06-10 | — | — | WO | claimed |
| EP-2367817-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | Via Pharmaceuticals, Inc. (US) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010065310-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | VIA PHARMACEUTICALS, INC (US) | 2010-06-10 | — | — | WO | disclosed |