Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 2/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.47 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.47 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | CDC25B | P30305 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7029687 | 0.90 | PDE3A (0.55) | PDE3APDE3BPIK3CDPIK3CAPIK3CB | |
| SCHEMBL5058597 | 0.84 | PDE3B (0.62) | PDE3APDE3BPIK3CDPIK3CAPIK3CB | |
| SCHEMBL30096326 | 0.84 | FGFR1 (0.47) | PARP14ERCC1DNASE1FEN1ERCC4 | |
| SCHEMBL21676438 | 0.78 | OPRM1 (0.52) | PDE3APDE3BPIK3CDPIK3CAPIK3CB | |
| SCHEMBL6407854 | 0.77 | PARP1 (0.51) | PDE3APDE3BPIK3CDPIK3CAPIK3CB | |
| SCHEMBL6645304 | 0.77 | PIK3CD (0.49) | PDE3APDE3BPIK3CDPIK3CAPIK3CB | |
| SCHEMBL30662844 | 0.76 | HSD17B10 (0.73) | PDE3APDE3BPIK3CDPIK3CAPIK3CB | |
| SCHEMBL26610914 | 0.76 | HSD17B10 (0.73) | PDE3APDE3BPIK3CDPIK3CAPIK3CB | |
| SCHEMBL3425392 | 0.75 | ALDH1A1 (0.44) | PDE3APDE3BAPAF1CDC25BCASP3 | |
| SCHEMBL7023134 | 0.75 | PDE3A (0.62) | PDE3APDE3BERCC1DNASE1FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547664-B1 | MORPHOLINYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2016-05-04 | — | — | EP | disclosed |
| EP-2547664-B1 | MORPHOLINYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2016-05-04 | — | — | EP | disclosed |
| US-9126952-B2 | Morpholinylquinazolines | MERCK PATENT GMBH (DE) | 2015-09-08 | — | — | US | disclosed |
| US-9126952-B2 | Morpholinylquinazolines | MERCK PATENT GMBH (DE) | 2015-09-08 | — | — | US | disclosed |
| US-9126952-B2 | Morpholinylquinazolines | MERCK PATENT GMBH (DE) | 2015-09-08 | — | — | US | disclosed |
| EP-2547664-A1 | MORPHOLINYLQUINAZOLINES | Merck Patent GmbH (DE) | 2013-01-23 | — | — | EP | disclosed |
| US-20130012489-A1 | Morpholinylquinazolines | MERCK PATENT GMBH (DE) | 2013-01-10 | — | — | US | disclosed |
| US-20130012489-A1 | Morpholinylquinazolines | MERCK PATENT GMBH (DE) | 2013-01-10 | — | — | US | disclosed |
| US-20130012489-A1 | Morpholinylquinazolines | MERCK PATENT GMBH (DE) | 2013-01-10 | — | — | US | disclosed |
| WO-2011113512-A1 | MORPHOLINYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011113512-A1 | MORPHOLINYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2011-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012489-A1 | Morpholinylquinazolines | LATS2, TNK2, SKP1 | PDE3A 3307/4885PDE3B 3211/4885PIK3CD 1763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.