Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | TNK1 | Q13470 | 4/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | CASP7 | P55210 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.46 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6645304 | 0.97 | PIK3CD (0.49) | PARP1PIK3CDPIK3CAPIK3CBTNK1 | |
| Hydrochloric Acid SCHEMBL6405673 | 0.80 | PARP1 (0.74) | PARP1TNK1TNK2KCNH2PARP2 | |
| SCHEMBL2424124 | 0.77 | PDE3A (0.56) | PARP1PIK3CDPIK3CAPIK3CBALDH1A1 | |
| Hydrochloric Acid SCHEMBL6403655 | 0.77 | PARP1 (0.60) | PARP1KDM4EKCNH2PARP2NQO1 | |
| SCHEMBL21676438 | 0.76 | OPRM1 (0.52) | PIK3CDPIK3CAPIK3CBALDH1A1KDM4E | |
| SCHEMBL6405680 | 0.75 | PARP1 (0.64) | PARP1TNK1TNK2KCNH2PARP2 | |
| SCHEMBL6406113 | 0.75 | KMT2A (0.46) | PARP1ALDH1A1KDM4EHSD17B10TSHR | |
| SCHEMBL1873116 | 0.74 | MAPT (0.55) | ALDH1A1KDM4ECASP1CASP7HSD17B10 | |
| SCHEMBL6555534 | 0.74 | DRD2 (0.54) | PARP1TNK1TNK2KCNH2PARP2 | |
| Hydrochloric Acid SCHEMBL6411449 | 0.73 | DRD2 (0.53) | PARP1TNK1TNK2KCNH2PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050171101-A1 | Phenanthridinones as parp inhibitors | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2005-08-04 | — | — | US | disclosed |
| EP-1487800-A1 | PHENANTHRIDINONES AS PARP INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003080581-A1 | PHENANTHRIDINONES AS PARP INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171101-A1 | Phenanthridinones as parp inhibitors | PARP1, PARP11, PARP2 | PARP1 1/4885PIK3CD 1105/4885PIK3CA 429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.