Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30931966 | 1.00 | LMNA (0.47) | LMNACCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL6070786 | 0.78 | LMNA (0.44) | LMNACCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL2965363 | 0.73 | LMNA (0.47) | LMNACCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL2238760 | 0.73 | BRAF (0.61) | LMNACCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL2963770 | 0.73 | LMNA (0.47) | LMNACCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL12783513 | 0.71 | LMNA (0.48) | LMNACCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL16877199 | 0.71 | LMNA (0.42) | LMNACCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL1456892 | 0.70 | HCAR2 (0.41) | LMNAALDH1A1PARP1POLBTDP1 | |
| SCHEMBL27018053 | 0.70 | LMNA (0.47) | LMNACCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL6132086 | 0.70 | TGFBR1 (0.50) | LMNACCNA2CDK2CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112689528-B | Pyrimidinyl-heteroaryloxy-naphthyl compounds and methods of use | 基因泰克公司 | 2024-05-14 | — | — | CN | disclosed |
| EP-3849663-B1 | PYRIMIDINYL-HETEROARYLOXY-NAPHTHYL COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2023-08-02 | — | — | EP | disclosed |
| US-20220048888-A1 | PYRIMIDINYL-HETEROARYLOXY-NAPHTHYL COMPOUNDS AND METHODS OF USE | GENENTECH, INC. | 2022-02-17 | — | — | US | disclosed |
| CN-112689528-A | Pyrimidinyl-heteroaryloxy-naphthyl compounds and methods of use | 基因泰克公司 | 2021-04-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220048888-A1 | PYRIMIDINYL-HETEROARYLOXY-NAPHTHYL COMPOUNDS AND METHODS OF USE | XBP1, HSPA5, HSP90B1 | LMNA 1242/4885CCNA2 4262/4885CDK2 2271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.