SCHEMBL24251440

SCHEMBL24251440

Cc1nn2c(C(C)C)c(C(=O)NC3CCc4sccc43)ccc2c1-c1c(F)cccc1F

nearest known ligand 0.39

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ PDE10A Q9Y233 4/20 0.39
▸ TAS1R3 Q7RTX0 2/20 0.36
▸ TAS1R1 Q7RTX1 2/20 0.36
▸ TAS1R2 Q8TE23 2/20 0.36
▸ LMNA P02545 1/20 0.34
▸ PDE2A O00408 1/20 0.30
▸ NOD1 Q9Y239 1/20 0.30
▸ HHAT Q5VTY9 2/20 0.30
▸ DHODH Q02127 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24251583 0.87 PDE10A (0.44) PDE10ATAS1R3TAS1R1TAS1R2PDE2A
SCHEMBL24251374 0.86 TAS1R3 (0.49) PDE10ATAS1R3TAS1R1TAS1R2PDE2A
SCHEMBL24251394 0.85 TAS1R3 (0.37) PDE10ATAS1R3TAS1R1TAS1R2PDE2A
SCHEMBL24251580 0.84 PDE10A (0.41) PDE10ATAS1R3TAS1R1TAS1R2PDE2A
SCHEMBL24251390 0.84 PDE10A (0.43) PDE10ATAS1R3TAS1R1TAS1R2LMNA
SCHEMBL24251386 0.83 TAS1R3 (0.47) PDE10ATAS1R3TAS1R1TAS1R2
SCHEMBL24251512 0.82 TAS1R3 (0.43) TAS1R3TAS1R1TAS1R2PDE2A
SCHEMBL23355416 0.82 BRD4 (0.40) TAS1R3TAS1R1TAS1R2
SCHEMBL24251524 0.82 TAS1R3 (0.36) PDE10ATAS1R3TAS1R1TAS1R2PDE2A
SCHEMBL24251354 0.82 BRD4 (0.40) TAS1R3TAS1R1TAS1R2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220048903-A1 Anthelminthic Heterocyclic Compounds BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2022-02-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220048903-A1 Anthelminthic Heterocyclic Compounds SDHA, PAH, PIGS PDE10A 1700/4885TAS1R3 4103/4885TAS1R1 3604/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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