Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.54 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 7/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.47 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.42 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.41 |
| ▸ | USP5 | P45974 | 1/20 | 0.41 |
| ▸ | USP4 | Q13107 | 1/20 | 0.41 |
| ▸ | ACP3 | P15309 | 2/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL5679956 | 0.90 | PDE4A (0.45) | MMP3BCL2L1PDE4APDE4BPDE4C | |
| Phosphoric Acid SCHEMBL1199529 | 0.90 | PDE4A (0.45) | MMP3BCL2L1PDE4APDE4BPDE4C | |
| Phosphoric Acid SCHEMBL1900203 | 0.89 | HDAC4 (0.46) | MMP3BCL2L1PDE4APDE4BPDE4C | |
| SCHEMBL29287283 | 0.89 | MMP3 (0.67) | MMP3BCL2L1PDE4APDE4BPDE4C | |
| Pyrophosphoric Acid SCHEMBL1901228 | 0.89 | PDE4A (0.47) | MMP3BCL2L1PDE4APDE4BPDE4C | |
| Phosphoric Acid SCHEMBL34467592 | 0.85 | MMP3 (0.75) | MMP3BCL2L1ESR1ESR2DEGS1 | |
| Phosphoric Acid SCHEMBL2214342 | 0.85 | MMP3 (0.75) | MMP3BCL2L1ESR1ESR2DEGS1 | |
| Phenol SCHEMBL28986147 | 0.83 | MMP3 (0.71) | MMP3BCL2L1ESR1ESR2DEGS1 | |
| Biphenyl SCHEMBL28415908 | 0.83 | MMP3 (0.70) | MMP3BCL2L1ESR1ESR2DEGS1 | |
| SCHEMBL20323157 | 0.82 | MMP3 (0.78) | MMP3BCL2L1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022122-B2 | Derivatives of pyrimidines as flame retardants | BASF SE (DE) | 2011-09-20 | — | — | US | disclosed |
| EP-2013279-B1 | DERIVATIVES OF PYRIMIDINES AS FLAME RETARDANTS | BASF SE (DE) | 2010-03-31 | — | — | EP | disclosed |
| US-20090131565-A1 | Derivatives of Pyrimidines as Flame Retardants | BASF SE (DE) | 2009-05-21 | — | — | US | disclosed |
| EP-2013279-A1 | DERIVATIVES OF PYRIMIDINES AS FLAME RETARDANTS | Ciba Holding Inc. (CH) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007128678-A1 | DERIVATIVES OF PYRIMIDINES AS FLAME RETARDANTS | CIBA HOLDING INC. (CH) | 2007-11-15 | — | — | WO | disclosed |